Introduction：Basic information about CAS 38274-54-3|Benurestat, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Benurestat |
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| CAS Number | 38274-54-3 | Molecular Weight | 228.63200 |
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| Density | 1.414g/cm3 | Boiling Point | / |
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| Molecular Formula | C9H9ClN2O3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-chloro-N-[2-(hydroxyamino)-2-oxoethyl]benzamide |
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| Synonym | More Synonyms |
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Benurestat BiologicalActivity
| Description | Benurestat is an orally active urease inhibitor. Benurestat can be used for infected ureolysis research[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vivo | Benurestat administration, 25 mg/kg, 50 mg/kg, or 100 mg/kg, causes a decrease in the urinary excretion of ammonia from rats with experimental P. mirabilis genitourinary tract infection[1]. The number of viable bacteria present in the bladders of infected rats is significantly less after the administration of Benurestat plus Nitrofurantoin, Sulfamethoxazole, or Ampicillin than the respective numbers that are obtained from control infected rats or from rats administered either component of the combination separately[1]. |
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| References | [1]. J A Andersen. Benurestat, a urease inhibitor for the therapy of infected ureolysis. Invest Urol. 1975 Mar;12(5):381-6. |
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Chemical & Physical Properties
| Density | 1.414g/cm3 |
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| Molecular Formula | C9H9ClN2O3 |
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| Molecular Weight | 228.63200 |
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| Exact Mass | 228.03000 |
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| PSA | 78.43000 |
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| LogP | 1.35700 |
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| Index of Refraction | 1.59 |
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| InChIKey | JFZGBMJPJZDNNT-UHFFFAOYSA-N |
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| SMILES | O=C(CNC(=O)c1ccc(Cl)cc1)NO |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- AK8317000
- CHEMICAL NAME :
- Acetohydroxamic acid, 2-(p-chlorobenzamido)-
- CAS REGISTRY NUMBER :
- 38274-54-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C9-H9-Cl-N2-O3
- MOLECULAR WEIGHT :
- 228.65
- WISWESSER LINE NOTATION :
- QMV1MVR DG
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- DNA repair
- TEST SYSTEM :
- Bacteria - Bacillus subtilis
- DOSE/DURATION :
- 10 umol/disc
- REFERENCE :
- JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 3,557,1980
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2924299090 |
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Customs
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| EU-2826 |
| Benurstat |
| Benurestat |
