CAS 731862-92-3|Mal-C6-amine TFA

Introduction：Basic information about CAS 731862-92-3|Mal-C6-amine TFA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Mal-C6-amine TFA BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Mal-C6-amine TFA
CAS Number	731862-92-3	Molecular Weight	310.270
Density	/	Boiling Point	/
Molecular Formula	C₁₂H₁₇F₃N₂O₄	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	1-(6-Aminohexyl)-1H-pyrrole-2,5-dione 2,2,2-trifluoroacetate
Synonym	More Synonyms

Mal-C6-amine TFA BiologicalActivity

Description	Mal-C6-amine (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

Molecular Formula	C₁₂H₁₇F₃N₂O₄
Molecular Weight	310.270
Exact Mass	310.114044
PSA	100.70000
LogP	1.70200
InChIKey	RBQIUIPYPXTLRY-UHFFFAOYSA-N
SMILES	NCCCCCCN1C(=O)C=CC1=O.O=C(O)C(F)(F)F

Safety Information

Hazard Codes	Xi
HS Code	2925190090

Customs

HS Code	2925190090
Summary	2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Synonyms

1-(6-aminohexyl)pyrrole-2,5-dione,2,2,2-trifluoroacetic acid

1-(6-Aminohexyl)-1H-pyrrole-2,5-dione trifluoroacetate (1:1)

Acetic acid, 2,2,2-trifluoro-, compd. with 1-(6-aminohexyl)-1H-pyrrole-2,5-dione (1:1)

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