Introduction：Basic information about CAS 67909-49-3|Dehydroevodiamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dehydroevodiamine |
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| CAS Number | 67909-49-3 | Molecular Weight | 301.342 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C19H15N3O | Melting Point | 216-218ºC |
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| MSDS | / | Flash Point | / |
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Names
| Name | Dehydroevodiamine |
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| Synonym | More Synonyms |
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Dehydroevodiamine BiologicalActivity
| Description | Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes[1]. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells[2]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COXSignaling Pathways >>Immunology/Inflammation >>PGE synthase |
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| Target | iNOS; COX-2; PGE2; NF-κB[2] |
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| In Vitro | Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages[2]. Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS-induced increase in the iNOS and COX-2 mRNA expression[2]. Western Blot Analysis[2] Cell Line: RAW 264.7 macrophage cells Concentration: 10 μM, 30 μM, 50 μM Incubation Time: pretreated 2 hours Result: Reduced iNOS and COX-2 expression and increased IκB-α expression. RT-PCR[2] Cell Line: RAW 264.7 macrophage cells Concentration: 10 μM, 30 μM, 50 μM Incubation Time: pretreated 2 hours Result: Reduced iNOS and COX-2 mRNA expression. |
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| References | [1]. Loh SH, et al. Antiarrhythmic effects of dehydroevodiamine in isolated human myocardium and cardiomyocytes. J Ethnopharmacol. 2014 May 14;153(3):753-62. [2]. Noh EJ, et al. Inhibition of lipopolysaccharide-induced iNOS and COX-2 expression by dehydroevodiamine through suppression of NF-kappaB activation in RAW 264.7 macrophages. Life Sci. 2006 Jul 10;79(7):695-701. Epub 2006 Mar 6. |
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Chemical & Physical Properties
| Melting Point | 216-218ºC |
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| Molecular Formula | C19H15N3O |
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| Molecular Weight | 301.342 |
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| Exact Mass | 301.121521 |
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| PSA | 38.77000 |
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| LogP | 2.15950 |
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| InChIKey | VXHNSVKJHXSKKM-UHFFFAOYSA-N |
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| SMILES | CN1C2=C3N=c4ccccc4=C3CCN2C(=O)c2ccccc21 |
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| Storage condition | 2-8C |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Indolo[2',3':3,4]pyrido[2,1-b]quinazolinium, 5,7,8,13-tetrahydro-14-methyl-5-oxo-, inner salt |
| 14-Methyl-5-oxo-7,8-dihydro-5H-indolo[2',3':3,4]pyrido[2,1-b]quinazolin-14-ium-13-ide |
| 14-Methyl-5-oxo-7,8-dihydro-5H-indolo[2',3':3,4]-pyrido[2,1-b]quinazolin-14-ium-13-ide |
