CAS 114676-59-4|D-Proline, 4-hydroxy-, methyl ester hydrochloride

Introduction：Basic information about CAS 114676-59-4|D-Proline, 4-hydroxy-, methyl ester hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	D-Proline, 4-hydroxy-, methyl ester hydrochloride
CAS Number	114676-59-4	Molecular Weight	181.617
Density	/	Boiling Point	/
Molecular Formula	C₆H₁₂ClNO₃	Melting Point	121-123 ºC
MSDS	/	Flash Point	/

Names

Name	D-Proline, 4-hydroxy-, methyl ester, (Hydrochloride) (1:1), (4R)
Synonym	More Synonyms

BiologicalActivity

Description	D-Proline, 4-hydroxy-, methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). D-Proline, 4-hydroxy-, methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2
Related Catalog	Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

Melting Point	121-123 ºC
Molecular Formula	C₆H₁₂ClNO₃
Molecular Weight	181.617
Exact Mass	181.050568
PSA	58.56000
LogP	0.01300
InChIKey	KLGSHNXEUZOKHH-TYSVMGFPSA-N
SMILES	COC(=O)C1CC(O)CN1.Cl

Synonyms

D-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1)

Trans-4-hydroxy-L-proline methyl ester hydrochloride

Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1)

Methyl (4R)-4-hydroxy-D-prolinate hydrochloride (1:1)

CIS-4-HYDROXY-D-PROLINE METHYL ESTER

L-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1)

cis-4-hydroxy-D-proline methyl ester hydrochloride

methyl cis 4-hydroxyl-D-proline

(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid methyl ester hydrochloride

(2R,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride

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