Introduction：Basic information about CAS 73218-79-8|Iopidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Iopidine |
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| CAS Number | 73218-79-8 | Molecular Weight | 281.56900 |
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| Density | 1.63 g/cm3 | Boiling Point | 395.5ºC at 760 mmHg |
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| Molecular Formula | C9H11Cl3N4 | Melting Point | >230ºC |
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| MSDS | ChineseUSA | Flash Point | 193ºC |
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| Symbol |
GHS06, GHS08 | Signal Word | Danger |
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Names
| Name | apraclonidine hydrochloride |
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| Synonym | More Synonyms |
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Iopidine BiologicalActivity
| Description | Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| In Vitro | Apraclonidine hydrochloride (ALO 2145) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects[2]. |
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| In Vivo | Apraclonidine hydrochloride (ALO 2145) is effective in animal models of elevated IOP as well as glaucoma in humans. The ocular hypotensive effects of Apraclonidine are usually attributed to reduced aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery[2]. |
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| References | [1]. Wijemanne S, et al. Apraclonidine in the treatment of ptosis. J Neurol Sci. 2017;376:129‐132. [2]. Searles RV, et al. Aqueous humor dynamics in anesthetized rats infused with intracameral apraclonidine. Pharmacology. 1999;58(4):220‐226. |
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Chemical & Physical Properties
| Density | 1.63 g/cm3 |
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| Boiling Point | 395.5ºC at 760 mmHg |
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| Melting Point | >230ºC |
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| Molecular Formula | C9H11Cl3N4 |
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| Molecular Weight | 281.56900 |
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| Flash Point | 193ºC |
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| Exact Mass | 280.00500 |
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| PSA | 62.44000 |
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| LogP | 3.16730 |
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| InChIKey | OTQYGBJVDRBCHC-UHFFFAOYSA-N |
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| SMILES | Cl.Nc1cc(Cl)c(NC2=NCCN2)c(Cl)c1 |
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| Storage condition | 2-8°C |
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| Stability | Moisture Sensitive |
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| Water Solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 mg/mL Solutions may be stored for several days at 4?#x00b0;C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CZ1582000
- CHEMICAL NAME :
- 1,4-Benzenediamine, 2,6-dichloro-N(sup 1)-(4,5-dihydro-1H-imidazol-2-yl)-, monohydrochloride
- CAS REGISTRY NUMBER :
- 73218-79-8
- LAST UPDATED :
- 199604
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C9-H10-Cl2-N4.Cl-H
- MOLECULAR WEIGHT :
- 281.59
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 38 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 24,557,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 24,557,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 24,557,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 24,557,1988
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Safety Information
| Symbol |
GHS06, GHS08 |
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| Signal Word | Danger |
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| Hazard Statements | H300-H370 |
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| Precautionary Statements | Missing Phrase - N15.00950417-P308 + P311 |
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| Target Organs | Cardio-vascular system |
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| Hazard Codes | T: Toxic; |
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| Risk Phrases | R23/24/25 |
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| Safety Phrases | 22-36/37/39-45 |
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| RIDADR | UN 2811 |
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| WGK Germany | 3 |
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| Packaging Group | III |
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| Hazard Class | 6.1(b) |
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| HS Code | 2933290090 |
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Customs
| HS Code | 2933290090 |
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| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| UNII-D2VW67N38H |
| Iopidine ophthalmic solution |
| MFCD00135922 |
| 2-(4-Amino-2,6-dichlorophenylimino)imidazolidine |
| 2-[(4-amino-2,6-dichlorophenyl)imino]imidazolidine monohydrochloride |
| APRACLONIDINE HYDROCHLORIDE |
| ALO-2145 |
| 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine,hydrochloride |
| p-aminoclonidine hydrochloride |
| NC 14 hydrochloride |
| 2-[(2,6-dichloro-4-aminophenyl)imino]imidazolidine hydrochloride |
| p-aminoclonidine |
| mono hydrochloride |
| Apraclonidine HCl |
