CAS 676-46-0|Sodium DL-Malate

Introduction：Basic information about CAS 676-46-0|Sodium DL-Malate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Sodium DL-Malate BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles42
8. Synonyms

Common Name	Sodium DL-Malate
CAS Number	676-46-0	Molecular Weight	178.051
Density	/	Boiling Point	306.4ºC at 760 mmHg
Molecular Formula	C₄H₄Na₂O₅	Melting Point	> 300°C (Lit.)
MSDS	USA	Flash Point	153.4ºC

Names

Name	Sodium 2-hydroxysuccinate
Synonym	More Synonyms

Sodium DL-Malate BiologicalActivity

Description	Sodium DL-Malate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Related Catalog	Research Areas >>Others

Chemical & Physical Properties

Boiling Point	306.4ºC at 760 mmHg
Melting Point	> 300°C (Lit.)
Molecular Formula	C₄H₄Na₂O₅
Molecular Weight	178.051
Flash Point	153.4ºC
Exact Mass	177.985413
PSA	100.49000
InChIKey	WPUMTJGUQUYPIV-UHFFFAOYSA-L
SMILES	O=C([O-])CC(O)C(=O)[O-].[Na+].[Na+]
Storage condition	Store below +30°C.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ON7730000

CHEMICAL NAME :: Malic acid, sodium salt

CAS REGISTRY NUMBER :: 676-46-0

LAST UPDATED :: 199504

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C4-H4-O5.2Na

MOLECULAR WEIGHT :: 178.06

WISWESSER LINE NOTATION :: QV1YQVO &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - excitement Behavioral - muscle weakness

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 25,467,1925

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore, MD 21202) V.1- 1905- Volume(issue)/page/year: 28,185,1917 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4709 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2440 (estimated) No. of Female Employees: 1459 (estimated)

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
RTECS	ON7730000
HS Code	2917190090

Customs

HS Code	2917190090
Summary	2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles42

Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates.

Bioorg. Med. Chem. Lett. 15 , 573-8, (2005)

A detailed inhibition study of five carbonic anhydrase (CA, EC 4.2.1.1) isozymes with carboxylates including aliphatic (formate, acetate), dicarboxylic (oxalate, malonate), hydroxy/keto acids (l-lacta...

GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy.

Am. J. Physiol. Renal Physiol. 304(11) , F1317-24, (2013)

Early diagnosis of diabetic nephropathy (DN) is difficult although it is of crucial importance to prevent its development. To probe potential markers and the underlying mechanism of DN, an animal mode...

In vitro reactive oxygen species production by mitochondria from the rabbitfish Siganus fuscessens livers and the effects of Irgarol-1051.

Environ. Toxicol. Pharmacol. 35(2) , 154-60, (2013)

In this study, the mitochondria from the livers of Siganus fuscessens were exposed to the Irgarol-1051with or without respiratory chain inhibitors using succinate or malate as the substrate, and the e...

Synonyms

DL-Malic acid disodium salt

Disodium DL-malate

Disodium malate

UNII:2EFF9N315F

Sodium DL-Malate

Butanedioic acid, 2-hydroxy-, sodium salt (1:2)

Hydroxybutanedioic acid disodium salt

MFCD00012466

Butanedioic acid, hydroxy-, disodium salt

disodium 2-hydroxybutanedioate

Sodium malate

EINECS 211-627-6

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