CAS 6877-32-3|Corynoxine

Introduction：Basic information about CAS 6877-32-3|Corynoxine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Corynoxine BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Corynoxine
CAS Number	6877-32-3	Molecular Weight	384.469
Density	1.2±0.1 g/cm3	Boiling Point	560.8±50.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₈N₂O₄	Melting Point	166-168ºC
MSDS	/	Flash Point	293.0±30.1 °C

Names

Name	Corynoxine
Synonym	More Synonyms

Corynoxine BiologicalActivity

Description	Corynoxine is an enantiomer of Corynoxine B; induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.IC50 value:Tareget: Autophagy inducerIn vivo, Cory promotes the formation of autophagosomes in the fat bodies of Drosophila. By inducing autophagy, Cory promotes the clearance of wild-type and A53T α-syn in inducible PC12 cells. Interestingly, different from its enantiomer Cory B, Cory induces autophagy through the Akt/mTOR pathway as evidenced by the reduction in the levels of phospho-Akt, phospho-mTOR and phospho-p70 S6 Kinase [1]. Corynoxine significantly decreased locomotor activity after oral administration to mice [2].
Related Catalog	Signaling Pathways >>Autophagy >>AutophagyNatural Products >>AlkaloidResearch Areas >>Cancer
References	[1]. Chen LL, et al. Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway. J Neuroimmune Pharmacol. 2014 Jun;9(3):380-7. [2]. Sakakibara I, et al. Effect on locomotion of indole alkaloids from the hooks of uncaria plants. Phytomedicine. 1999 Jul;6(3):163-8.

Description

Corynoxine is an enantiomer of Corynoxine B; induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.IC50 value:Tareget: Autophagy inducerIn vivo, Cory promotes the formation of autophagosomes in the fat bodies of Drosophila. By inducing autophagy, Cory promotes the clearance of wild-type and A53T α-syn in inducible PC12 cells. Interestingly, different from its enantiomer Cory B, Cory induces autophagy through the Akt/mTOR pathway as evidenced by the reduction in the levels of phospho-Akt, phospho-mTOR and phospho-p70 S6 Kinase [1]. Corynoxine significantly decreased locomotor activity after oral administration to mice [2].

Related Catalog

Signaling Pathways >>Autophagy >>AutophagyNatural Products >>AlkaloidResearch Areas >>Cancer

References

[1]. Chen LL, et al. Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway. J Neuroimmune Pharmacol. 2014 Jun;9(3):380-7.

[2]. Sakakibara I, et al. Effect on locomotion of indole alkaloids from the hooks of uncaria plants. Phytomedicine. 1999 Jul;6(3):163-8.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	560.8±50.0 °C at 760 mmHg
Melting Point	166-168ºC
Molecular Formula	C₂₂H₂₈N₂O₄
Molecular Weight	384.469
Flash Point	293.0±30.1 °C
Exact Mass	384.204895
PSA	67.87000
LogP	3.31
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.596
InChIKey	DAXYUDFNWXHGBE-NRAMRBJXSA-N
SMILES	CCC1CN2CCC3(C(=O)Nc4ccccc43)C2CC1C(=COC)C(=O)OC
Storage condition	-20°C

Synonyms

Methyl (16E)-16-(methoxymethylene)-2-oxocorynoxan-17-oate

Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,3S,6'S,7'S,8'aS)-

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