CAS 1585-68-8|Catalpalactone

Introduction：Basic information about CAS 1585-68-8|Catalpalactone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Catalpalactone BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Catalpalactone
CAS Number	1585-68-8	Molecular Weight	258.269
Density	1.3±0.1 g/cm3	Boiling Point	467.1±45.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₄O₄	Melting Point	/
MSDS	/	Flash Point	245.2±27.1 °C

Names

Name	3-(2,2-dimethyl-6-oxo-3H-pyran-5-yl)-3H-2-benzofuran-1-one
Synonym	More Synonyms

Catalpalactone BiologicalActivity

Description	Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities[1][2].
Related Catalog	Research Areas >>Inflammation/Immunology
References	[1]. Kim HY, et al. Anti-Inflammatory Effects of Catalpalactone Isolated from Catalpa ovata in LPS-Induced RAW264.7 Cells. Molecules. 2019 Mar 29;24(7):1236. [2]. Huang HS, et al. Effects of catalpalactone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Environ Toxicol Pharmacol. 2008 Jul;26(1):86-91.

Description

Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities[1][2].

Related Catalog

Research Areas >>Inflammation/Immunology

References

[1]. Kim HY, et al. Anti-Inflammatory Effects of Catalpalactone Isolated from Catalpa ovata in LPS-Induced RAW264.7 Cells. Molecules. 2019 Mar 29;24(7):1236.

[2]. Huang HS, et al. Effects of catalpalactone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Environ Toxicol Pharmacol. 2008 Jul;26(1):86-91.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	467.1±45.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₄O₄
Molecular Weight	258.269
Flash Point	245.2±27.1 °C
Exact Mass	258.089203
PSA	52.60000
LogP	2.05
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.576
InChIKey	GFYSRANGENPXDF-UHFFFAOYSA-N
SMILES	CC1(C)CC=C(C2OC(=O)c3ccccc32)C(=O)O1

Synonyms

3-(5,6-Dihydro-6,6-dimethyl-2-oxo-2H-pyran-3-yl)-1(3H)-isobenzofuranone

1(3H)-Isobenzofuranone, 3-(5,6-dihydro-6,6-dimethyl-2-oxo-2H-pyran-3-yl)-

Catalpalactone

3-(6,6-Dimethyl-2-oxo-5,6-dihydro-2H-pyran-3-yl)-2-benzofuran-1(3H)-one

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