CAS 900185-01-5|PIK-293
Introduction：Basic information about CAS 900185-01-5|PIK-293, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | PIK-293 | ||
|---|---|---|---|
| CAS Number | 900185-01-5 | Molecular Weight | 397.433 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 657.3±65.0 °C at 760 mmHg |
| Molecular Formula | C22H19N7O | Melting Point | / |
| MSDS | / | Flash Point | 351.3±34.3 °C |
Names
| Name | 2-[(4-aminopyrazolo[3,4-d]pyrimidin-1-yl)methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one |
|---|---|
| Synonym | More Synonyms |
PIK-293 BiologicalActivity
| Description | PIK-293, an analog of IC87114, is a PI3K inhibitor, with IC50 values of 0.24 μM, 10 μM, 25 μM and 100 μM for p110δ, p110β, p110γ and p110α, respectively[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>PI3KResearch Areas >>Metabolic Disease |
| Target | PI3Kδ:0.24 μM (IC50) PI3Kβ:10 μM (IC50) PI3Kγ:25 μM (IC50) PI3Kα:100 μM (IC50) |
| References | [1]. Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 657.3±65.0 °C at 760 mmHg |
| Molecular Formula | C22H19N7O |
| Molecular Weight | 397.433 |
| Flash Point | 351.3±34.3 °C |
| Exact Mass | 397.165100 |
| PSA | 104.51000 |
| LogP | 2.18 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.759 |
| InChIKey | KQDBVHKNIYROHU-UHFFFAOYSA-N |
| SMILES | Cc1ccccc1-n1c(Cn2ncc3c(N)ncnc32)nc2cccc(C)c2c1=O |
| Storage condition | -20℃ |
Synonyms
| PIK-293-Supplied by Selleck Chemicals |
| S2207_Selleck |
| cc-612 |
| 2-((4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one |
| X7412 |
| 2-[(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone |
| 4(3H)-Quinazolinone, 2-[(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl]-5-methyl-3-(2-methylphenyl)- |
| PIK-293 |
