CAS 128470-16-6|Arbutamine

Introduction：Basic information about CAS 128470-16-6|Arbutamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Arbutamine BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Arbutamine
CAS Number	128470-16-6	Molecular Weight	317.38000
Density	1.262g/cm3	Boiling Point	578.3ºC at 760mmHg
Molecular Formula	C₁₈H₂₃NO₄	Melting Point	/
MSDS	/	Flash Point	195.1ºC

Names

Name	arbutamine
Synonym	More Synonyms

Arbutamine BiologicalActivity

Description	Arbutamine is a short-acting synthetic potent nonselective β-adrenoceptor agonist that increases heart rate, cardiac contractility, and systolic blood pressure[1]. Arbutamine is a catecholamine for a pharmacological cardiac stress agen[2].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor
Target	β-adrenoceptor[1]
In Vivo	Arbutamine (i.v.; 5, 10, 50, 100, and 250 ng/kg/min) increases mean heart rate, peak positive left ventricular pressure and its first time-derivative, and normal-zone myocardial thickening in 8 open-chest dogs (mean weight, 26.91 kg).
References	[1]. Ruiz M, et al. Arbutamine stress perfusion imaging in dogs with critical coronary artery stenoses: (99m)Tc-sestamibi versus (201)Tl. J Nucl Med. 2002 May;43(5):664-70. [2]. Nagarajan R, et al. A novel catecholamine, arbutamine, for a pharmacological cardiac stress agent. Cardiovasc Drugs Ther. 1996 Mar;10(1):31-8.

Chemical & Physical Properties

Density	1.262g/cm3
Boiling Point	578.3ºC at 760mmHg
Molecular Formula	C₁₈H₂₃NO₄
Molecular Weight	317.38000
Flash Point	195.1ºC
Exact Mass	317.16300
PSA	92.95000
LogP	2.84020
InChIKey	IIRWWTKISYTTBL-SFHVURJKSA-N
SMILES	Oc1ccc(CCCCNCC(O)c2ccc(O)c(O)c2)cc1

Synonyms

4-[(1R)-1-Hydroxy-2-{[4-(4-hydroxyphenyl)butyl]amino}ethyl]-1,2-b enzenediol

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