CAS 147362-57-0|Loviride

Introduction：Basic information about CAS 147362-57-0|Loviride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Loviride BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Loviride
CAS Number	147362-57-0	Molecular Weight	351.22700
Density	1.354g/cm3	Boiling Point	550.3ºC at 760mmHg
Molecular Formula	C₁₇H₁₆Cl₂N₂O₂	Melting Point	226.3 °C
MSDS	/	Flash Point	286.6ºC

Names

Name	2-(2-acetyl-5-methylanilino)-2-(2,6-dichlorophenyl)acetamide
Synonym	More Synonyms

Loviride BiologicalActivity

Description	Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with IC50s of 0.3 µM for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells[1].
Related Catalog	Signaling Pathways >>Anti-infection >>HIVResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>Reverse Transcriptase
Target	IC50: 0.3 µM (Reverse transcriptase)[1]
In Vitro	Loviride (0.01 µM) inhibits HIV-1(IIIB) replication in MT-4 cells, also inhibits HIV-2 and SIV, with EC50s of 85.5, 7.4 µM for HIV-2 (ROD), HIV-2 (EHO), and 11.4, 28.5, 57.0 µM for SIV (mac251), SIV (agm3), SIV (mndGB1), respectively[1].
References	[1]. Witvrouw M, et al. Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV. AIDS. 1999 Aug 20;13(12):1477-83.

Chemical & Physical Properties

Density	1.354g/cm3
Boiling Point	550.3ºC at 760mmHg
Melting Point	226.3 °C
Molecular Formula	C₁₇H₁₆Cl₂N₂O₂
Molecular Weight	351.22700
Flash Point	286.6ºC
Exact Mass	350.05900
PSA	73.18000
LogP	5.36560
Vapour Pressure	3.69E-12mmHg at 25°C
Index of Refraction	1.637
InChIKey	CJPLEFFCVDQQFZ-UHFFFAOYSA-N
SMILES	CC(=O)c1ccc(C)cc1NC(C(N)=O)c1c(Cl)cccc1Cl

Synonyms

Loveride

Loviride (USAN/INN)

loviride

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