Introduction：Basic information about CAS 145459-19-4|Heterophyllin B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Heterophyllin B |
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| CAS Number | 145459-19-4 | Molecular Weight | 778.937 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 1159.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C40H58N8O8 | Melting Point | / |
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| MSDS | / | Flash Point | 655.1±34.3 °C |
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Names
| Name | Cyclo(glycylglycyl-L-isoleucyl-L-prolyl-L-prolyl-L-prolyl-L-isole ucyl-L-phenylalanyl) |
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| Synonym | More Synonyms |
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Heterophyllin B BiologicalActivity
| Description | Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla. Heterophyllin B provides a novel strategy for the treatment of esophageal cancer[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>PI3K |
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| In Vitro | Heterophyllin B (0-200 µM; 12-48 hours) reduces cell viability in the 75, 100 and 200 µM groups, has no effect on 5, 10, 25 and 50 µM groups[1]. Heterophyllin B (0-50 µM; 6 hours) suppresses the expression levels of p-PI3K, p-AKT and β-catenin in a dose-dependent manner in ECA-109 cells[1]. Cell Viability Assay[1] Cell Line: ECA-109 cells Concentration: 5 µM, 10 µM, 25 µM, 50 µM, 75 µM, 100 µM and 200 µM Incubation Time: 12, 24 and 48 hours Result: Decreased cell viability at high concentrations. Western Blot Analysis[1] Cell Line: ECA-109 cells Concentration: 0 µM, 10 µM, 25 µM, 50 µM Incubation Time: 6 hours Result: Decreased the phosphorylation of PI3K/AKT and the expression of β-catenin. |
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| References | [1]. Tantai JC, et al. Heterophyllin B inhibits the adhesion and invasion of ECA-109 human esophageal carcinoma cells by targeting PI3K/AKT/β-catenin signaling. Mol Med Rep. 2016 Feb;13(2):1097-104. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 1159.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C40H58N8O8 |
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| Molecular Weight | 778.937 |
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| Flash Point | 655.1±34.3 °C |
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| Exact Mass | 778.437744 |
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| PSA | 223.88000 |
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| LogP | -1.82 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.604 |
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| InChIKey | KYAVLJJQNUHRMR-PPLFBOPFSA-N |
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| SMILES | CCC(C)C1NC(=O)C2CCCN2C(=O)C2CCCN2C(=O)C2CCCN2C(=O)C(CC(C)C)NC(=O)CNC(=O)CNC(=O)C(Cc2ccccc2)NC1=O |
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Synonyms
| Cyclo(glycylglycyl-L-leucyl-L-prolyl-L-prolyl-L-prolyl-L-isoleucyl-L-phenylalanyl) |
| Heterophyllin B |
