Introduction：Basic information about CAS 14348-38-0|4-Bromo-3-hydroxybenzoic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4-Bromo-3-hydroxybenzoic acid |
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| CAS Number | 14348-38-0 | Molecular Weight | 217.017 |
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| Density | 1.9±0.1 g/cm3 | Boiling Point | 338.6±32.0 °C at 760 mmHg |
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| Molecular Formula | C7H5BrO3 | Melting Point | 225-227ºC |
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| MSDS | / | Flash Point | 158.6±25.1 °C |
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Names
| Name | 4-Bromo-3-hydroxybenzoic acid |
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| Synonym | More Synonyms |
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4-Bromo-3-hydroxybenzoic acid BiologicalActivity
| Description | 4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC50s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC50s of 1 mM for both enzymes[1][2]. |
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| Related Catalog | Research Areas >>Neurological Disease |
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| In Vitro | IC50: 1 mM (Rat fetal histidine decarboxylase (HDC)), 1 mM (Ratgastric HDC), 1 mM (Hog kidney aromatic-L-amino acid decarboxylase), 1 mM (Rat gastric mucosa aromatic-L-amino acid decarboxylase)[1] |
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| References | [1]. Ellenbogen L, et al. Studies on the inhibition of histidine decarboxylase, aromatic-L-amino acid decarboxylase and acid secretion by brocresine and its metabolites. Biochem Pharmacol. 1973 Apr 15;22(8):939-47. [2]. Qian S, et al. Inhibiting Histamine Signaling Ameliorates Vertigo Induced by Sleep Deprivation. J Mol Neurosci. 2019 Mar;67(3):411-417. |
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Chemical & Physical Properties
| Density | 1.9±0.1 g/cm3 |
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| Boiling Point | 338.6±32.0 °C at 760 mmHg |
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| Melting Point | 225-227ºC |
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| Molecular Formula | C7H5BrO3 |
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| Molecular Weight | 217.017 |
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| Flash Point | 158.6±25.1 °C |
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| Exact Mass | 215.942200 |
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| PSA | 57.53000 |
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| LogP | 2.68 |
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| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
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| Index of Refraction | 1.655 |
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| InChIKey | PAJSESFUWIYFNF-UHFFFAOYSA-N |
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| SMILES | O=C(O)c1ccc(Br)c(O)c1 |
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Safety Information
| Hazard Codes | Xi: Irritant; |
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| HS Code | 2918290000 |
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Customs
| HS Code | 2918290000 |
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| Summary | HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| 4-Bromo-3-hydroxybenzoic acid |
| Benzoic acid, 4-bromo-3-hydroxy- |
