CAS 14317-68-1|[Asu1,6]-Oxytocin

Introduction:Basic information about CAS 14317-68-1|[Asu1,6]-Oxytocin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name[Asu1,6]-Oxytocin
CAS Number14317-68-1Molecular Weight956.09600
Density1.216g/cm3Boiling Point1475.3ºC at 760 mmHg
Molecular FormulaC45H69N11O12Melting Point/
MSDS/Flash Point846ºC

Names

Namedeamino-dicarba-oxytocin
SynonymMore Synonyms

[Asu1,6]-Oxytocin BiologicalActivity

Description[Asu1,6]-Oxytocin is an analog of oxytocin. [Asu1,6]-Oxytocin reverses insulin resistance and glucose intolerance prior to reduction of obesity. [Asu1,6]-Oxytocin has the potential for the research of obesity and diabetes[1].
Related CatalogSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease
In Vivo[Asu1,6]-Oxytocin (4 μg per injection; third-ventricle injection, twice injected for 7 days) 改善小鼠的葡萄糖耐受不良并降低空腹血胰岛素水平[1]。 Animal Model: C57BL/6 mice[1] Dosage: 4 μg per injection Administration: Third-ventricle injection, twice injected for 7 days Result: Improved glucose intolerance and lowered fasting blood insulin levels, and both effects were independent of body weight.
References

[1]. Zhang H, et al. Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models. PLoS One. 2013 May 20;8(5):e61477.  

Chemical & Physical Properties

Density1.216g/cm3
Boiling Point1475.3ºC at 760 mmHg
Molecular FormulaC45H69N11O12
Molecular Weight956.09600
Flash Point846ºC
Exact Mass955.51300
PSA373.51000
LogP2.09780
Vapour Pressure0mmHg at 25°C
Index of Refraction1.531
InChIKeyBNUVXRORJOWJBK-DTRKZRJBSA-N
SMILESCCC(C)C1NC(=O)C(Cc2ccc(O)cc2)NC(=O)CCCCCC(C(=O)N2CCCC2C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC1=O

Synonyms

tyr-ile-gln-asn-asu-pro-leu-gly-nh2
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