Introduction：Basic information about CAS 219137-97-0|Ac-Val-Glu-Ile-Asp-AMC, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ac-Val-Glu-Ile-Asp-AMC |
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| CAS Number | 219137-97-0 | Molecular Weight | 673.711 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 1106.8±65.0 °C at 760 mmHg |
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| Molecular Formula | C32H43N5O11 | Melting Point | / |
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| MSDS | / | Flash Point | 623.2±34.3 °C |
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Names
| Name | ac-veid-amc |
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| Synonym | More Synonyms |
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Ac-Val-Glu-Ile-Asp-AMC BiologicalActivity
| Description | Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm)[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| In Vitro | Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). Enzyme activity (rabbit osteoclasts for example)[1]: 1. Treat purified, differentiated cells by medium for 48 h (time depends on the cell). 2. Put treated cells into 4.5 mL lysis buffer. 3. Each lysate is divided into thirds, then incubate with 40 µM Ac-VEID-AMC at 37°C for 1 h. 4. Detect cleavage of fluorescent substrates (Ex=340-360 nm, Em=440-460 nm) |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 1106.8±65.0 °C at 760 mmHg |
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| Molecular Formula | C32H43N5O11 |
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| Molecular Weight | 673.711 |
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| Flash Point | 623.2±34.3 °C |
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| Exact Mass | 673.295898 |
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| PSA | 250.31000 |
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| LogP | 2.36 |
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| Appearance of Characters | powder | white |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.571 |
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| InChIKey | QMXIJZDGCJEANV-YPBMFZGESA-N |
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| SMILES | CCC(C)C(NC(=O)C(CCC(=O)O)NC(=O)C(NC(C)=O)C(C)C)C(=O)NC(CC(=O)O)C(=O)Nc1ccc2c(C)cc(=O)oc2c1 |
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| Storage condition | −20°C |
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Synonyms
| L-α-Asparagine, N-acetyl-L-valyl-L-α-glutamyl-L-isoleucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- |
| Ac-Val-Glu-IIe-Asp-7-amino-4-methylcoumarin |
| N-Acetyl-L-valyl-L-α-glutamyl-L-isoleucyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-α-asparagine |
| AC-VAL-GLU-ILE-ASP-MCA |
| AC-VEID-MCA |
| PASE-6 SUBSTRATE I,FLUOROGENIC |
| AC-VAL-GLU-ILE-ASP-AMC |
| N-ACETYL-VAL-GLU-ILE-ASP-7-AMINO-4-METHYLCOUMARIN AMC |
| AC-VAL-GLU-ILE-ASP-7-AMINO-4-METHYLCOUMARIN |
