CAS 432531-71-0|necrosulfonamide

Introduction：Basic information about CAS 432531-71-0|necrosulfonamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. necrosulfonamide BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	necrosulfonamide
CAS Number	432531-71-0	Molecular Weight	461.472
Density	1.6±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₁₈H₁₅N₅O₆S₂	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Necrosulfonamide
Synonym	More Synonyms

necrosulfonamide BiologicalActivity

Description	(E/Z)-Necrosulfonamide is a racemic compound of Necrosulfonamide (HY-100573). Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis[1][2].
Related Catalog	Research Areas >>CancerSignaling Pathways >>MAPK/ERK Pathway >>Mixed Lineage Kinase
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Sun L, et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 2012;148(1-2):213-227.

Description

(E/Z)-Necrosulfonamide is a racemic compound of Necrosulfonamide (HY-100573). Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis[1][2].

Related Catalog

Research Areas >>CancerSignaling Pathways >>MAPK/ERK Pathway >>Mixed Lineage Kinase

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Sun L, et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 2012;148(1-2):213-227.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Molecular Formula	C₁₈H₁₅N₅O₆S₂
Molecular Weight	461.472
Exact Mass	461.046387
PSA	195.95000
LogP	4.08
Index of Refraction	1.695
InChIKey	FNPPHVLYVGMZMZ-XBXARRHUSA-N
SMILES	COc1nccnc1NS(=O)(=O)c1ccc(NC(=O)C=Cc2ccc([N+](=O)[O-])s2)cc1

Safety Information

Hazard Codes	Xi

Synonyms

(E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide

(2E)-N-{4-[(3-Methoxy-2-pyrazinyl)sulfamoyl]phenyl}-3-(5-nitro-2-thienyl)acrylamide

2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-, (2E)-

necrosulfonamide

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