Introduction：Basic information about CAS 514-66-9|Rubropunctamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Rubropunctamine |
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| CAS Number | 514-66-9 | Molecular Weight | 353.41200 |
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| Density | 1.22g/cm3 | Boiling Point | 647.1ºC at 760 mmHg |
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| Molecular Formula | C21H23NO4 | Melting Point | / |
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| MSDS | / | Flash Point | 345.1ºC |
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Names
| Name | (9aR)-3-hexanoyl-9a-methyl-6-[(E)-prop-1-enyl]-7H-furo[3,2-g]isoquinoline-2,9-dione |
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| Synonym | More Synonyms |
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Rubropunctamine BiologicalActivity
| Description | Rubropunctamine is a red azaphilone pigment isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctamine has anti-inflammation activities[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| In Vitro | Rubropunctamine (0.32-32 nM; 48 h) inhibits Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), with an IC50 of 433 mol ratio/32 pmol TPA[1]. Rubropunctamine (1 h) exhibits moderate scavenging activity (inhibitory ratio (IR)=1.5) against NO generation by (±)-(E)-methyl-2[(E)-hydroxy-imino]-5-nitro-6-methoxy-3-hexemide (NOR 1) in normal human hepato cells[1]. |
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| In Vivo | Rubropunctamine inhibits TPA-induced inflammation in mice, with an ID50 of 0.32 mg/ear[1]. |
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| References | [1]. Akihisa T, et, al. Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects. J Agric Food Chem. 2005 Feb 9;53(3):562-5. [2]. Patakova P. Monascus secondary metabolites: production and biological activity. J Ind Microbiol Biotechnol. 2013 Feb;40(2):169-81. |
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Chemical & Physical Properties
| Density | 1.22g/cm3 |
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| Boiling Point | 647.1ºC at 760 mmHg |
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| Molecular Formula | C21H23NO4 |
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| Molecular Weight | 353.41200 |
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| Flash Point | 345.1ºC |
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| Exact Mass | 353.16300 |
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| PSA | 76.23000 |
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| LogP | 3.06720 |
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| Index of Refraction | 1.59 |
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| InChIKey | WTEXYKPGDKLLCW-CLFFMEQDSA-N |
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| SMILES | CC=Cc1cc2c(cn1)C(=O)C1(C)OC(=O)C(=C(O)CCCCC)C1=C2 |
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Synonyms
