Introduction：Basic information about CAS 55084-08-7|Skullcapflavone II, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Skullcapflavone II |
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| CAS Number | 55084-08-7 | Molecular Weight | 374.341 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 636.9±55.0 °C at 760 mmHg |
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| Molecular Formula | C19H18O8 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 230.9±25.0 °C |
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Names
| Name | scullcapflavone II |
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| Synonym | More Synonyms |
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Skullcapflavone II BiologicalActivity
| Description | Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Skullcapflavone II inhibits osteoclastogenesis with decreased activation of MAPKs, Src, and cAMP response element-binding protein (CREB), which have been known to be redox sensitive. Skullcapflavone II decreases reactive oxygen species by scavenging them or activating nuclear factor-erythroid 2-related factor 2 (Nrf2), and its effects were partially reversed by hydrogen peroxide cotreatment or Nrf2 deficiency[2]. |
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| In Vivo | Skullcapflavone II, a potential bradykinin antagonist, reduces the major pathophysiological features of allergic asthma, at least in part by acting on TGF-β1/Smad signaling pathways[3]. |
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| References | [1]. Solnier J, et al. Flavonoids as Novel Efflux Pump Inhibitors and Antimicrobials Against Both Environmental and Pathogenic Intracellular Mycobacterial Species. Molecules. 2020;25(3):734. Published 2020 Feb 7. [2]. Lee J, et al. Skullcapflavone II inhibits osteoclastogenesis by regulating reactive oxygen species and attenuates the survival and resorption function of osteoclasts by modulating integrin signaling. FASEB J. 2019;33(2):2026-2036. [3]. Jang HY, et al. Skullcapflavone II inhibits ovalbumin-induced airway inflammation in a mouse model of asthma [published correction appears in Int Immunopharmacol. 2013 Sep;17(1):154]. Int Immunopharmacol. 2012;12(4):666-674. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 636.9±55.0 °C at 760 mmHg |
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| Molecular Formula | C19H18O8 |
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| Molecular Weight | 374.341 |
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| Flash Point | 230.9±25.0 °C |
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| Exact Mass | 374.100159 |
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| PSA | 107.59000 |
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| LogP | 1.58 |
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| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
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| Index of Refraction | 1.613 |
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| InChIKey | GMQFOKBGMKVUQZ-UHFFFAOYSA-N |
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| SMILES | COc1cccc(O)c1-c1cc(=O)c2c(O)c(OC)c(OC)c(OC)c2o1 |
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Safety Information
| RIDADR | NONH for all modes of transport |
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| HS Code | 2914509090 |
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Customs
| HS Code | 2914509090 |
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| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| 5-Hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-4H-chromen-4-one |
| Neobaicalein |
| Skullcapflavone II |
| 5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxychromen-4-one |
| 5,2'-Dihydroxy-6,7,8,6'-tetramethoxyflavone |
| 4H-1-Benzopyran-4-one, 5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy- |
| Scullcapflavone II |
