Introduction：Basic information about CAS 958295-17-5|AGN 196996, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | AGN 196996 |
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| CAS Number | 958295-17-5 | Molecular Weight | 482.32300 |
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| Density | 1.453±0.06 g/cm3 (20 °C, 760 mmHg) | Boiling Point | 619.8±55.0 °C (760 mmHg) |
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| Molecular Formula | C24H20BrNO5 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Benzoic acid, 4-[[3-bromo-4-ethoxy-5-(4-methylbenzoyl)benzoyl]amino] |
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| Synonym | More Synonyms |
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AGN 196996 BiologicalActivity
| Description | AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).IC50 value: 2 nM(Ki)Target: RARα antagonistAGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>RAR/RXRResearch Areas >>Cancer |
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| References | [1]. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62. [2]. Keedwell RG, et al. An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8. |
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Chemical & Physical Properties
| Density | 1.453±0.06 g/cm3 (20 °C, 760 mmHg) |
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| Boiling Point | 619.8±55.0 °C (760 mmHg) |
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| Molecular Formula | C24H20BrNO5 |
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| Molecular Weight | 482.32300 |
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| Exact Mass | 481.05200 |
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| PSA | 92.70000 |
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| LogP | 5.41070 |
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| InChIKey | BUGXGZOGQGUTBC-UHFFFAOYSA-N |
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| SMILES | CCOc1c(Br)cc(C(=O)Nc2ccc(C(=O)O)cc2)cc1C(=O)c1ccc(C)cc1 |
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| Storage condition | 2-8℃ |
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Synonyms
