Introduction：Basic information about CAS 1421438-81-4|Crenigacestat(LY3039478), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Crenigacestat(LY3039478) |
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| CAS Number | 1421438-81-4 | Molecular Weight | 464.438 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 818.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C22H23F3N4O4 | Melting Point | / |
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| MSDS | / | Flash Point | 448.9±34.3 °C |
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Names
| Name | N-[(1S)-2-[[(7S)-6,7-Dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluorobutanamide |
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| Synonym | More Synonyms |
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Crenigacestat(LY3039478) BiologicalActivity
| Description | Crenigacestat (LY3039478) is a novel and potent Notch inhibitor. |
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| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>NotchResearch Areas >>Cancer |
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| In Vivo | In a xenograft tumor model, Crenigacestat (LY3039478) inhibit N1ICD cleavage and expression of Notch-regulated genes in the tumor microenvironment. Crenigacestat (LY3039478) is being investigated in Phase I. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 818.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C22H23F3N4O4 |
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| Molecular Weight | 464.438 |
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| Flash Point | 448.9±34.3 °C |
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| Exact Mass | 464.167145 |
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| PSA | 111.63000 |
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| LogP | 1.83 |
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| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
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| Index of Refraction | 1.594 |
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| InChIKey | YCBAQKQAINQRFW-UGSOOPFHSA-N |
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| SMILES | CC(NC(=O)CCC(F)(F)F)C(=O)NC1C(=O)N(CCO)c2ncccc2-c2ccccc21 |
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| Storage condition | -20℃ |
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Synonyms
| 4-trifluoro-N-((S)-1-(((S)-5-(2-hydroxyethyl)-6-oxo-6 |
| 3-b]azepin-7-yl)amino)-1-oxopropan-2-yl)butanamide |
| 4,4,4-Trifluoro-N-[(2S)-1-{[(7S)-5-(2-hydroxyethyl)-6-oxo-6,7-dihydro-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino}-1-oxo-2-propanyl]butanamide |
| Butanamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluoro- |
| UNII:923X28214S |
| Crenigacestat |
| LY3039478 |
| LY-3039478 |
