CAS 1219803-84-5|Cetirizine-d4
Introduction：Basic information about CAS 1219803-84-5|Cetirizine-d4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cetirizine-d4 | ||
|---|---|---|---|
| CAS Number | 1219803-84-5 | Molecular Weight | 392.91200 |
| Density | / | Boiling Point | / |
| Molecular Formula | C21H21D4ClN2O3 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | Cetirizine-D4 |
|---|---|
| Synonym | More Synonyms |
Cetirizine-d4 BiologicalActivity
| Description | Cetirizine D4 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
| Target | H1 receptor |
| References | [1]. Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055•1080, 1993. [2]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5. [3]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9. |
Chemical & Physical Properties
| Molecular Formula | C21H21D4ClN2O3 |
|---|---|
| Molecular Weight | 392.91200 |
| Exact Mass | 392.18000 |
| PSA | 53.01000 |
| LogP | 3.02400 |
| InChIKey | ZKLPARSLTMPFCP-QZPARXMSSA-N |
| SMILES | O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1 |
Synonyms
| (±)-Cetirizine-d4 (ethoxy-d4) |
| (±)-Cetirizine-d4 |
