CAS 206752-36-5|Benzenecarboximidamide hydrochloride hydrate
| Common Name | Benzenecarboximidamide hydrochloride hydrate | ||
|---|---|---|---|
| CAS Number | 206752-36-5 | Molecular Weight | 174.628 |
| Density | / | Boiling Point | 208.5ºC at 760mmHg |
| Molecular Formula | C7H8N2.ClH.xH2O | Melting Point | 86-88 °C(lit.) |
| MSDS | USA | Flash Point | 79.9ºC |
Names
| Name | benzenecarboximidamide,hydrate,hydrochloride |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | Benzenecarboximidamide, hydrochloride, hydrate (1:1:x) (Benzamidine hydrochloride hydrate) is a reversible competitive trypsin-like serine proteases inhibitor with Kis of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Ser/Thr ProteaseResearch Areas >>Cancer |
| Target | Ki: 20 μM (Tryptase), 21 μM (Trypsin), 97 μM (uPA), 110 μM (Factor Xa), 320 μM (Thrombin), 750 μM (tPA)[1] |
| References | [1]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312. [2]. Tanizawa K, et al. Proteolytic enzymes. VI. Aromatic amidines as competitive inhibitors of trypsin. J Biochem. 1971 May;69(5):893-9. |
Chemical & Physical Properties
| Boiling Point | 208.5ºC at 760mmHg |
|---|---|
| Melting Point | 86-88 °C(lit.) |
| Molecular Formula | C7H8N2.ClH.xH2O |
| Molecular Weight | 174.628 |
| Flash Point | 79.9ºC |
| Exact Mass | 174.055984 |
| PSA | 59.10000 |
| LogP | 2.50840 |
| Vapour Pressure | 0.213mmHg at 25°C |
| InChIKey | BQVJCMMLDJPBFZ-UHFFFAOYSA-N |
| SMILES | Cl.N=C(N)c1ccccc1.O |
| Storage condition | 0-6°C |
| Water Solubility | soluble |
Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | CV6260000 |
Articles6
More Articles| Preparation of extracts from yeast. Meth. Enzymol. 182 , 154, (1990) | |
| Thermodynamics of the interaction between oxytocin and its myometrial receptor in sheep: a stepwise binding mechanism. Biochem. Pharmacol. 91(1) , 119-27, (2014) Entropy (ΔS), enthalpy (ΔH) and heat capacity (ΔCp) changes attending the oxytocin interaction with its two binding sites on myometrial cell membranes in sheep were derived from the temperature depend... | |
| Synthesis and characterization of a lubricin mimic (mLub) to reduce friction and adhesion on the articular cartilage surface. Biomaterials 73 , 42-50, (2015) The lubricating proteoglycan, lubricin, facilitates the remarkable low friction and wear properties of articular cartilage in the synovial joints of the body. Lubricin lines the joint surfaces and pla... |
Synonyms
| EINECS 216-795-4 |
| Benzenecarboximidamide hydrochloride hydrate |
| Benzamidine HCl Hydrate |
| MFCD00066285 |
| Benzenecarboximidamide, hydrochloride, hydrate (1:1:1) |
| AMIDINOBENZENE HYDROCHLORIDE |
| Benzamidine hydrochloride, hydrate |
| Benzamidine hydrochloride hydrate |
| Benzamidine Hydrochloride Monohydrate |
| Benzamidinium chloride |
