CAS 2140-79-6|2'-O-Methyladenosine
| Common Name | 2'-O-Methyladenosine | ||
|---|---|---|---|
| CAS Number | 2140-79-6 | Molecular Weight | 281.268 |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 623.8±65.0 °C at 760 mmHg |
| Molecular Formula | C11H15N5O4 | Melting Point | 200-202ºC |
| MSDS | USA | Flash Point | 331.0±34.3 °C |
Names
| Name | cordysinin B |
|---|---|
| Synonym | More Synonyms |
2'-O-Methyladenosine BiologicalActivity
| Description | 2'-O-Methyladenosine, a methylated adenine residue is found in urine of normals as well as in urine of adenosine deaminase (ADA) deficient patients. 2'-O-Methyladenosine exhibits unique hypotensive activities [1][2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
| In Vivo | 2'-O-Methyladenosine (100, 200 mg/kg, ip, single dose) exhibits unique hypotensive activities in rats[2]. Animal Model: Male spontaneously hypertensive rats (SHR; 16 weeks old)[2]. Dosage: 100, 200 mg/kg. Administration: IP, single dose. Result: Exhibited a significant hypotensive effect in decreasing blood pressure by about 40-50%. |
| References | [1]. Hirschhorn R, et al. Increased excretion of modified adenine nucleosides by children with adenosine deaminase deficiency. Pediatr Res. 1982 May;16(5):362-9. [2]. Yamada T, et al. Naturally occurring 2'-O-methylpurine nucleosides with hypotensive properties. Cell Mol Life Sci. 1998 Feb;54(2):125-8. |
Chemical & Physical Properties
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 623.8±65.0 °C at 760 mmHg |
| Melting Point | 200-202ºC |
| Molecular Formula | C11H15N5O4 |
| Molecular Weight | 281.268 |
| Flash Point | 331.0±34.3 °C |
| Exact Mass | 281.112396 |
| PSA | 128.54000 |
| LogP | -0.15 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.795 |
| InChIKey | FPUGCISOLXNPPC-IOSLPCCCSA-N |
| SMILES | COC1C(O)C(CO)OC1n1cnc2c(N)ncnc21 |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles15
More Articles| Increased excretion of modified adenine nucleosides by children with adenosine deaminase deficiency. Pediatr. Res. 16(5) , 362-9, (1982) We have identified seven adenine nucleosides in urines of untreated adenosine deaminase (ADA) deficient patients, four of which (adenosine, 2'-deoxyadenosine, 1-methyladenosine and N6-methyladenosine)... | |
| Stabilizing effects of the RNA 2'-substituent: crystal structure of an oligodeoxynucleotide duplex containing 2'-O-methylated adenosines. Chem. Biol. 1(1) , 39-45, (1994) The stability of hybrids of 2'-O-methyl-ribonucleotides with complementary RNA is considerably higher than that of the corresponding DNA.RNA duplexes. The 2'-O-modified ribonucleotides are thus an att... | |
| Effect of PGE2 and of agents that raise cAMP levels on macrophage activation induced by IFN-gamma and TNF-alpha. J. Leukoc. Biol. 58(2) , 217-24, (1995) The effect of prostaglandin (PG) E2 on macrophage activation by interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) was evaluated. Murine macrophages infected with Leishmania enri... |
Synonyms
| UNII-02YX82IHZ5 |
| 2'-O-Methyl adenosine |
| 2'-methyl-adenosine |
| 2'-O-methylAdo |
| 2′-O-Methyladenosine |
| (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol |
| 2'-methoxyadenosine |
| 2'-OMeAdenosine |
| MFCD00056002 |
| Adenosine, 2'-O-methyl- |
| 2'-O-Methyladenosine |
| 2'-O-Methyl-D-adenosine |
| (2R,3R,4R,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol |
| Adenosine,2'-O-methyl |
