Introduction：Basic information about CAS 1198-84-1|p-Hydroxymandelic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | p-Hydroxymandelic acid |
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| CAS Number | 1198-84-1 | Molecular Weight | 168.14700 |
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| Density | 1.48 g/cm3 | Boiling Point | 405.4ºC at 760 mmHg |
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| Molecular Formula | C8H8O4 | Melting Point | 82-85 °C(lit.) |
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| MSDS | / | Flash Point | 213.1ºC |
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Names
| Name | 4-hydroxymandelic acid |
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| Synonym | More Synonyms |
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p-Hydroxymandelic acid BiologicalActivity
| Description | p-Hydroxymandelic acid is a valuable aromatic fine chemical and widely used for production of pharmaceuticals and food additives. |
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| Related Catalog | Research Areas >>OthersNatural Products >>Acids and Aldehydes |
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| Target | Human Endogenous Metabolite |
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| In Vitro | p-Hydroxymandelic acid (4-Hydroxymandelic acid; 4-HMA) is widely used in production of aromatic drugs and flavors. It is employed for the preparation of 4-hydroxyphenylacetic acid, which is the synthetic precursor of selective β1-receptor antagonist drug atenolol. p-Hydroxymandelic acid can conjugate cytotoxic drug and enzyme substrate, and such a p-Hydroxymandelic acid based adaptor system showed promising application in the targeting drug delivery system[1]. |
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| References | [1]. Li FF, et al. Engineering Escherichia coli for production of 4-hydroxymandelic acid using glucose-xylosemixture. Microb Cell Fact. 2016 May 27;15:90. |
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Chemical & Physical Properties
| Density | 1.48 g/cm3 |
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| Boiling Point | 405.4ºC at 760 mmHg |
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| Melting Point | 82-85 °C(lit.) |
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| Molecular Formula | C8H8O4 |
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| Molecular Weight | 168.14700 |
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| Flash Point | 213.1ºC |
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| Exact Mass | 168.04200 |
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| PSA | 77.76000 |
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| LogP | 0.51020 |
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| InChIKey | YHXHKYRQLYQUIH-UHFFFAOYSA-N |
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| SMILES | O=C(O)C(O)c1ccc(O)cc1 |
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| Storage condition | -20°C |
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Safety Information
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36 |
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| WGK Germany | 3 |
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| HS Code | 2918290000 |
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Customs
| HS Code | 2918290000 |
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| Summary | HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| EINECS 214-839-7 |
| 4-Hydroxyphenylglycolic Acid |
| P-Hydroxy Mandelic Acid |
| 2-Hydroxy-2-(4-hydroxyphenyl)acetic acid |
| MFCD00004234 |
