Introduction：Basic information about CAS 703-95-7|5-Fluoroorotic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5-Fluoroorotic acid |
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| CAS Number | 703-95-7 | Molecular Weight | 174.087 |
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| Density | 1.8±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C5H3FN2O4 | Melting Point | 278 °C (dec.)(lit.) |
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| MSDS | Chinese | Flash Point | / |
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Names
| Name | 5-Fluoroorotic Acid |
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| Synonym | More Synonyms |
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5-Fluoroorotic acid BiologicalActivity
| Description | 5-Fluoroorotic is a selective agent in yeast molecular genetics. 5-Fluoroorotic possesses a well-expressed anticandidal effect close to that of 5-fluorocytosine, as well as moderate antidermatophytal effects[1][2]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Others >>Others |
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| References | [1]. Boeke JD, et, al. 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol. 1987; 154: 164-75. [2]. Nikolova K, et, al. Studies on the antimycotic activity of 5-fluoroorotic acid. Methods Find Exp Clin Pharmacol. 1987 Feb; 9(2): 85-9. |
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Chemical & Physical Properties
| Density | 1.8±0.1 g/cm3 |
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| Melting Point | 278 °C (dec.)(lit.) |
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| Molecular Formula | C5H3FN2O4 |
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| Molecular Weight | 174.087 |
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| Exact Mass | 174.007690 |
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| PSA | 103.02000 |
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| LogP | -1.00 |
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| Index of Refraction | 1.580 |
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| InChIKey | SEHFUALWMUWDKS-UHFFFAOYSA-N |
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| SMILES | O=C(O)c1[nH]c(=O)[nH]c(=O)c1F |
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| Storage condition | −20°C |
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| Water Solubility | NH4OH 4 M: 50 mg/mL, clear, faintly yellow |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UV7800000
- CHEMICAL NAME :
- 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-
- CAS REGISTRY NUMBER :
- 703-95-7
- LAST UPDATED :
- 198605
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C5-H3-F-N2-O4
- MOLECULAR WEIGHT :
- 174.10
- WISWESSER LINE NOTATION :
- T6VMVMJ EVQ FF
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 3,181,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 981 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975
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Safety Information
| Hazard Codes | Xn:Harmful; |
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| Risk Phrases | R22;R36/37/38 |
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| Safety Phrases | S26-S36 |
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| WGK Germany | 3 |
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| RTECS | UV7800000 |
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| HS Code | 2933599090 |
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Customs
| HS Code | 2933599090 |
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| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| EINECS 211-876-0 |
| 5-Fluoro-6-carboxyuracil |
| 4-Pyrimidinecarboxylic acid, 5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo- |
| 5-Fluoro orotic acid |
| 5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid |
| MFCD00042526 |
| 5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylic acid |
| Orotic acid, 5-fluoro- |
| 5-Fluoroorotic acid |
| 5-Fluoroorotic acid monohydrate |
