Introduction：Basic information about CAS 144481-98-1|Landiolol Hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Landiolol Hydrochloride |
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| CAS Number | 144481-98-1 | Molecular Weight | 546.053 |
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| Density | 1.201g/cm3 | Boiling Point | 727.5ºC at 760mmHg |
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| Molecular Formula | C25H40ClN3O8 | Melting Point | 122-127ºC |
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| MSDS | / | Flash Point | 393.8ºC |
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Names
| Name | Landiolol hydrochloride |
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| Synonym | More Synonyms |
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Landiolol Hydrochloride BiologicalActivity
| Description | Landiolol hydrochloride (ONO1101 hydrochloride) is a highly beta1 selective ultra-short acting beta-blocker (β1/β2 selectivity = 255:1, a half-life of 4 min)， acts as an adrenoceptor antagonist[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
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| Target | beta-adrenergic receptor[1] |
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| References | [1]. Atarashi H, et al. Pharmacokinetics of landiolol hydrochloride, a new ultra-short-acting beta-blocker, in patients with cardiac arrhythmias. Clin Pharmacol Ther. 2000 Aug;68(2):143-50. [2]. Okajima M, et al. Landiolol, an ultra-short-acting β1-blocker, is useful for managing supraventricular tachyarrhythmias in sepsis. World J Crit Care Med. 2015 Aug 4;4(3):251-7. |
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Chemical & Physical Properties
| Density | 1.201g/cm3 |
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| Boiling Point | 727.5ºC at 760mmHg |
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| Melting Point | 122-127ºC |
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| Molecular Formula | C25H40ClN3O8 |
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| Molecular Weight | 546.053 |
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| Flash Point | 393.8ºC |
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| Exact Mass | 545.250366 |
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| PSA | 127.82000 |
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| LogP | 2.37760 |
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| Vapour Pressure | 3.24E-22mmHg at 25°C |
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| InChIKey | DLPGJHSONYLBKP-IKGOIYPNSA-N |
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| SMILES | CC1(C)OCC(COC(=O)CCc2ccc(OCC(O)CNCCNC(=O)N3CCOCC3)cc2)O1.Cl |
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Safety Information
Synonyms
| ((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((S)-2-hydroxy-3-(2-(morpholine-4-carboxamido)ethylamino)propoxy)phenyl)propanoate hydrochloride |
| [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate hydrochloride |
| (-)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl-3-[4-[(S)-2-hydroxy-3-(2-morpholinocarbonylamino)ethylamino]propoxy]phenylpropionic acid hydrochloride |
| (-)-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(S)-2-hydroxy-3-(2-(morpholinocarbonylamino)ethylamino)propoxy]phenyl]propionate monohydrochloride |
| Benzenepropanoic acid,4-(2-hydroxy-3-((2-((4-morpholinylcarbonyl)amino)ethyl)amino)propoxy)-,(2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester,(S-(R*,R*))-,hydrochloride |
| Landiololhydrochloride |
| Benzenepropanoic acid, 4-[(2S)-2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-, [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester, hydrochloride (1:1) |
| Ono 1101 hydrochloride |
| 2,2-dimethyl-1,3-dioxolan-4S-yl-methyl 3-[P-{3-{(2-(morpholinocarbonylamino)ethyl)amino}-2S-hydroxypropoxy}phenyl] propionate hydrochloride |
| [(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methyl 3-{4-[(2S)-2-hydroxy-3-({2-[(4-morpholinylcarbonyl)amino]ethyl}amino)propoxy]phenyl}propanoate hydrochloride (1:1) |
