CAS 2687-91-4|N-Ethyl-2-pyrrolidone
| Common Name | N-Ethyl-2-pyrrolidone | ||
|---|---|---|---|
| CAS Number | 2687-91-4 | Molecular Weight | 113.158 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 203.6±0.0 °C at 760 mmHg |
| Molecular Formula | C6H11NO | Melting Point | < -120 °C |
| MSDS | ChineseUSA | Flash Point | 76.1±0.0 °C |
| Symbol | GHS05, GHS08 | Signal Word | Danger |
Names
| Name | N-Ethyl-2-pyrrolidone |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 203.6±0.0 °C at 760 mmHg |
| Melting Point | < -120 °C |
| Molecular Formula | C6H11NO |
| Molecular Weight | 113.158 |
| Flash Point | 76.1±0.0 °C |
| Exact Mass | 113.084061 |
| PSA | 20.31000 |
| LogP | 0.13 |
| Vapour Pressure | 0.3±0.4 mmHg at 25°C |
| Index of Refraction | 1.465 |
| InChIKey | ZFPGARUNNKGOBB-UHFFFAOYSA-N |
| SMILES | CCN1CCCC1=O |
| Storage condition | -70°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,475,1988 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1350 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes Liver - other changes Kidney, Ureter, Bladder - other changes
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,475,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4882359
Safety Information
| Symbol | GHS05, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H318-H360D |
| Precautionary Statements | P201-P280-P305 + P351 + P338 + P310-P308 + P313 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22;R36 |
| Safety Phrases | S26-S36 |
| WGK Germany | 1 |
| RTECS | UY5769250 |
| HS Code | 2933790090 |
Customs
| HS Code | 2933790090 |
|---|---|
| Summary | 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
Articles51
More Articles| Triptolide treatment reduces Alzheimer's disease (AD)-like pathology through inhibition of BACE1 in a transgenic mouse model of AD. Dis. Model Mech. 7(12) , 1385-95, (2014) The complex pathogenesis of Alzheimer's disease (AD) involves multiple contributing factors, including amyloid β (Aβ) peptide accumulation, inflammation and oxidative stress. Effective therapeutic str... | |
| Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells. Toxicol. Sci. 145 , 128-37, (2015) Levels of amyloid beta (Aβ) in the central nervous system are regulated by the balance between its synthesis and degradation. Neprilysin (NEP) is associated with Alzheimer's disease (AD) by its abilit... | |
| Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway. Molecular Neurodegeneration 10 , 56, (2015) Insulin degrading enzyme (IDE) is a major protease of amyloid beta peptide (Aβ), a prominent toxic protein in Alzheimer's disease (AD) pathogenesis. Previous studies suggested that statins promote IDE... |
Synonyms
| N-Ethyl-2-Pyrrolidone |
| 1-Ethyl-2-pyrrolidone |
| Agsol Ex 2 |
| 1-Ethyl-2-pyrrolidinone |
| N-Ethylpyrrolidone |
| N-Efhyl-2-Pyrrolidone |
| N-ethyl-2-pyrrolidinone |
| N-Ethyl-2-pyrrolidon |
| N-ethylpyrrolidinone |
| 2-Pyrrolidinone, 1-ethyl- |
| ethyl-2-pyrrolidone |
| N-Ethyl-a-pyrrolidone |
| 1-ethylpyrrolidin-2-one |
| N-Ethyl-2-azapentanone |
| NEP |
| EINECS 220-250-6 |
| ethyl-pyrrolidinone |
| MFCD00003199 |
| N-Ethyl-Pyrrolidone |
