CAS 20315-68-8|6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE
Introduction：Basic information about CAS 20315-68-8|6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE | ||
|---|---|---|---|
| CAS Number | 20315-68-8 | Molecular Weight | 202.25200 |
| Density | 1.198 g/cm3 | Boiling Point | 388.6ºC at 760 mmHg |
| Molecular Formula | C12H14N2O | Melting Point | 219-222ºC(lit.) |
| MSDS | ChineseUSA | Flash Point | 188.8ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.198 g/cm3 |
|---|---|
| Boiling Point | 388.6ºC at 760 mmHg |
| Melting Point | 219-222ºC(lit.) |
| Molecular Formula | C12H14N2O |
| Molecular Weight | 202.25200 |
| Flash Point | 188.8ºC |
| Exact Mass | 202.11100 |
| PSA | 37.05000 |
| LogP | 2.15100 |
| Vapour Pressure | 3.03E-06mmHg at 25°C |
| Index of Refraction | 1.639 |
| InChIKey | QYMDEOQLJUUNOF-UHFFFAOYSA-N |
| SMILES | COc1ccc2[nH]c3c(c2c1)CCNC3 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 415 mg/kg/5W-C
- TOXIC EFFECTS :
- Endocrine - changes in pituitary weight Related to Chronic Data - changes in ovarian weight Related to Chronic Data - changes in uterine weight
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,47,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 440 mg/kg/5W-I
- TOXIC EFFECTS :
- Vascular - regional or general arteriolar constriction Endocrine - changes in spleen weight Related to Chronic Data - changes in uterine weight
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,47,1978
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| RTECS | UV0725000 |
Articles26
More Articles| Melatonin and structurally-related compounds protect synaptosomal membranes from free radical damage. Int. J. Mol. Sci. 11 , 312-28, (2010) Since biological membranes are composed of lipids and proteins we tested the in vitro antioxidant properties of several indoleamines from the tryptophan metabolic pathway in the pineal gland against o... | |
| In vivo hepatic oxidative stress because of carbon tetrachloride toxicity: protection by melatonin and pinoline. J. Pineal Res. 49(1) , 78-85, (2010) The protective in vivo effects of melatonin or pinoline on carbon tetrachloride (CCl(4))-induced oxidative damage were investigated in liver of rats and compared to rats injected only with CCl(4) (5 m... | |
| Pinoline may be used as a probe for CYP2D6 activity. Drug Metab. Dispos. 37(3) , 443-6, (2009) Pinoline, 6-methoxy-1,2,3,4-tetrahydro-beta-carboline, is a serotonin analog that selectively inhibits the activity of monoamine oxidase-A and shows antidepressant activity. Our previous study using a... |
Synonyms
| MFCD00012071 |
| 6-methoxytryptoline |
| 6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole |
| 6-MeOthbc |
