CAS 153-78-6|2-aminofluorene

Introduction：Basic information about CAS 153-78-6|2-aminofluorene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 2-aminofluorene BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles34
8. Synonyms

Common Name	2-aminofluorene
CAS Number	153-78-6	Molecular Weight	181.233
Density	1.2±0.1 g/cm3	Boiling Point	379.3±21.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₁N	Melting Point	124-128 °C(lit.)
MSDS	USA	Flash Point	204.8±17.4 °C

Names

Name	2-Aminofluorene
Synonym	More Synonyms

2-aminofluorene BiologicalActivity

Description	2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis[1][4].
Related Catalog	Signaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisResearch Areas >>Others
In Vitro	2-Aminofluorene (0-100 μM, 1-5 days) produces a dose-related suppression of the antibody response to sheep erythrocytes (SRBC), DNP-Ficoll, and LPS[2]. 2-Aminofluorene (0-100 μM, 3 days, spleen cells) produces suppression on lymphoproliferative responses to LPS and Con A[2].
In Vivo	2-Aminofluorene (60 mg/kg, i.p.) accumulates twice the 2-Aminofluorene-DNA adducts of slow acetylators (A/J) in rapid acetylator mice (C57BL/6J)[3]. 2-Aminofluorene (60 mg/kg, i.p.) forms significantly higher levels of DNA adducts in tumor-target organs than in non-target organs in acetylator congenic hamsters[4].
References	[1]. Heflich RH, et al. Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites. Mutat Res. 1994 Oct;318(2):73-114. [2]. Kim BS, et al. Immunosuppressive effects of 2-acetylaminofluorene and 2-aminofluorene on murine splenocytes culture. Drug Chem Toxicol. 1989 Sep-Dec;12(3-4):297-311. [3]. Levy GN, et al. 2-Aminofluorene-DNA adduct formation in acetylator congenic mouse lines. Carcinogenesis. 1989 Apr;10(4):705-9.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	379.3±21.0 °C at 760 mmHg
Melting Point	124-128 °C(lit.)
Molecular Formula	C₁₃H₁₁N
Molecular Weight	181.233
Flash Point	204.8±17.4 °C
Exact Mass	181.089142
PSA	26.02000
LogP	2.88
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.697
Water Solubility	<0.1 g/100 mL at 19.5 ºC

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LL5075000

CHEMICAL NAME :: Fluoren-2-amine

CAS REGISTRY NUMBER :: 153-78-6

BEILSTEIN REFERENCE NO. :: 1945861

LAST UPDATED :: 199710

DATA ITEMS CITED :: 69

MOLECULAR FORMULA :: C13-H11-N

MOLECULAR WEIGHT :: 181.25

WISWESSER LINE NOTATION :: L B656 HHJ EZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 132 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3600 mg/kg/32W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 240 mg/kg/73W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg/26W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg/47W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11 gm/kg/34W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4000 mg/kg/23W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3200 mg/kg/58W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2420 mg/kg/23W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg/

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 gm/kg/30W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1080 mg/kg/30W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Liver - tumors

TYPE OF TEST :: DNA repair

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sperm Morphology

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - rabbit Lymphocyte

DOSE/DURATION :: 100 umol/L/30M

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,321,1978 *** REVIEWS *** TOXICOLOGY REVIEW 85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year: 5,63,1970

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R40;R68
Safety Phrases	S45-S36/37
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LL5075000
Packaging Group	I; II; III
Hazard Class	6.1
HS Code	29214980

Customs

HS Code	29214980

Articles34

Safety and mutagenicity evaluation of Vigiis 101 powder made from Lactobacillus paracasei subsp. paracasei NTU 101.

Regul Toxicol Pharmacol 71(2) , 148-57, (2015)

The aim of the present work was to assess the genotoxic activity and the potential for toxicity upon repeated dosing of "Vigiis 101" powder, a probiotic consisting of dried bacteria Lactobacillus para...

Safety assessment of dietary bamboo charcoal powder: a 90-day subchronic oral toxicity and mutagenicity studies.

Food Chem. Toxicol. 75 , 50-7, (2015)

Vegetable carbon has been used as food additive in EU (E153) and China for many years; however, no experimental data have been available on its dietary safety. This study was designed to evaluate the ...

Phytotoxicity and genotoxicity assessment of imazethapyr herbicide using a battery of bioassays.

Environ. Sci. Pollut. Res. Int. 22 , 19194-202, (2015)

The imazethapyr herbicide (formulation Verosil(®)) was evaluated for phytotoxicity and genotoxicity using a battery of bioassays: (1) the growth inhibition of the green alga Pseudokirchneriella subcap...

Synonyms

9H-Fluoren-2-amine

EINECS 205-817-8

2-aminofluorene

2-Amino fluorene

9H-Fluoren-2-ylamine

MFCD00001125

2-Fluorenamine

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