CAS 55-43-6|Dibenamine hydrochloride
Introduction：Basic information about CAS 55-43-6|Dibenamine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dibenamine hydrochloride | ||
|---|---|---|---|
| CAS Number | 55-43-6 | Molecular Weight | 296.23500 |
| Density | 1.107g/cm3 | Boiling Point | 320ºC at 760mmHg |
| Molecular Formula | C16H19Cl2N | Melting Point | 190-193 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 147.3ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | N-(2-Chloroethyl)dibenzylamine hydrochloride |
|---|---|
| Synonym | More Synonyms |
Dibenamine hydrochloride BiologicalActivity
| Description | Dibenamine hydrochloride is a competitive and irreversible adrenergic blocking agent and is known to modify the pharmacological effects of epinephrine. Dibenamine hydrochloride cause a significant increase in the rate of destruction of I-epinephrine in the mouse[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Metabolic Disease |
| Target | IC50: Adrenergic receptor[1] |
| In Vitro | Dibenamine (100 nM-10 μM) attenuates the degree of cocaine-induced increase in sensitivity to acetylcholine without any effect on acetylcholine-contraction in isolated vas deferens of guinea pig. Additionally, the degree of dibenamine-induced inhibition dependent on the concentration of dibenamine and inversely related to the concentration of cocaine[3]. |
| In Vivo | Dibenamine hydrochloride (subcutaneous injection; 25 mg/kg; 48 and 24 hr before the administration of CCl4) decreases the CHCl3, levels at 2 and 6 hr by 30-50 percent, but did not appreciably affect the half-life of CHCl3, in the liver.Pretreatment with Dibenamine apparently slows the conversion of Ccl4 to CHCL3[1]. |
| References | [1]. R W SCHAYER, et al. Effect of dibenamine (N-(2-chloroethyl) dibenzylamine) on the metabolism of radioactive epinephrine.J Biol Chem. 1953 May;202(1):39-43. [2]. H M Maling,et al. Nature of the protection against carbon tetrachloride-induced hepatotoxicity produced by pretreatment with dibenamine (N-(2-chloroethyl)dibenzylamine). Biochem Pharmacol. 1974 May 15;23(10):1479-91. [3]. K Araki, et al. Pharmacological studies on supersensitization. VII. Inhibitory effect of dibenamine on cocaine-induced supersensitivity of isolated vas deferens of guinea pig. J Pharmacobiodyn. 1982 Oct;5(10):789-95. |
Chemical & Physical Properties
| Density | 1.107g/cm3 |
|---|---|
| Boiling Point | 320ºC at 760mmHg |
| Melting Point | 190-193 °C(lit.) |
| Molecular Formula | C16H19Cl2N |
| Molecular Weight | 296.23500 |
| Flash Point | 147.3ºC |
| Exact Mass | 295.08900 |
| PSA | 3.24000 |
| LogP | 4.72960 |
| InChIKey | LZXCEBPGNFLHEQ-UHFFFAOYSA-N |
| SMILES | Cl.ClCCN(Cc1ccccc1)Cc1ccccc1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from small intestine
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,167,1947
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from small intestine
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,167,1947
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,167,1947
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 35 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 89,167,1947
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | S26-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | HQ6825000 |
| HS Code | 2921499090 |
Customs
| HS Code | 2921499090 |
|---|---|
| Summary | 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
Articles2
More Articles| Nature of the protection against carbon tetrachloride-induced hepatotoxicity produced by pretreatment with dibenamine (N-(2-chloroethyl)dibenzylamine). Biochem. Pharmacol. 23(10) , 1479-91, (1974) | |
| Effect of dibenamine (N-(2-chloroethyl) dibenzylamine) on the metabolism of radioactive epinephrine. J. Biol. Chem. 202(1) , 39-43, (1953) |
Synonyms
| N,N-dibenzyl-2-chloroethanamine,hydrochloride |
| MFCD00012518 |
| EINECS 200-234-5 |
