Introduction：Basic information about CAS 121961-22-6|Loracarbef hydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Loracarbef hydrate |
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| CAS Number | 121961-22-6 | Molecular Weight | 367.78400 |
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| Density | / | Boiling Point | 662.2ºC at 760 mmHg |
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| Molecular Formula | C16H16ClN3O4.H2O | Melting Point | 205-215° (dec) (Matsukuma) |
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| MSDS | / | Flash Point | 354.3ºC |
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Names
| Name | loracarbef (200 mg) |
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| Synonym | More Synonyms |
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Loracarbef hydrate BiologicalActivity
| Description | Loracarbef hydrate, a cephalosporin antibiotic, is an orally active second-generation synthetic beta-lactam antibiotic of the carbacephem class[1][2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Loracarbef hydrate demonstrates excellent activity against isolates of Escherichia coli and Klebsiella, Proteus and Salmonella species[2]. |
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| References | [1]. M Hu, et al. Mechanisms of Transport of Quinapril in Caco-2 Cell Monolayers: Comparison With Cephalexin. Pharm Res. 1995 Aug;12(8):1120-5. [2]. J W Dyke, et al. Antimicrobial Activity of New Antibiotics Against Bacterial Isolates From a Community Hospital. Chemotherapy. Sep-Oct 1993;39(5):315-21. |
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Chemical & Physical Properties
| Boiling Point | 662.2ºC at 760 mmHg |
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| Melting Point | 205-215° (dec) (Matsukuma) |
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| Molecular Formula | C16H16ClN3O4.H2O |
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| Molecular Weight | 367.78400 |
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| Flash Point | 354.3ºC |
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| Exact Mass | 367.09300 |
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| PSA | 121.96000 |
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| LogP | 1.67560 |
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| Vapour Pressure | 1.95E-18mmHg at 25°C |
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| InChIKey | GPYKKBAAPVOCIW-HSASPSRMSA-N |
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| SMILES | NC(C(=O)NC1C(=O)N2C(C(=O)O)=C(Cl)CCC12)c1ccccc1.O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CL6175600
- CHEMICAL NAME :
- 1-Azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-chloro-8-oxo-, monohydrate, (6R-(6-alpha,7-beta(R*)))-
- CAS REGISTRY NUMBER :
- 121961-22-6
- LAST UPDATED :
- 199506
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C16-H16-Cl-N3-O4.H2-O
- MOLECULAR WEIGHT :
- 367.82
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 43,60,1993
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| 1-Azabicyclo4.2.0oct-2-ene-2-carboxylic acid,7-(2R)-aminophenylacetylamino-3-chloro-8-oxo-,monohydrate,(6R,7S) |
| kt3777 |
| Carbacefaclor |
| 7-((aminophenylacetyl)amino)-3-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicaci |
