CAS 119139-23-0|Bisindolylmaleimide IV
| Common Name | Bisindolylmaleimide IV | ||
|---|---|---|---|
| CAS Number | 119139-23-0 | Molecular Weight | 327.336 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 690.1±55.0 °C at 760 mmHg |
| Molecular Formula | C20H13N3O2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 371.2±31.5 °C |
Names
| Name | Bisindolylmaleimide IV |
|---|---|
| Synonym | More Synonyms |
Bisindolylmaleimide IV BiologicalActivity
| Description | Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM)[1]. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Epigenetics >>PKCResearch Areas >>InfectionSignaling Pathways >>TGF-beta/Smad >>PKCSignaling Pathways >>Anti-infection >>CMV |
| Target | PKC:0.1-0.55 μM (IC50) HCMV:0.2 μM (IC50) |
| In Vitro | Bisindolylmaleimide IV (Arcyriarubin A) inhibits PKC with an IC50 of 0.1 μM in 1 % DMSO, while the IC50 of 0.55 μM in 10 % DMSO[1]. |
| References | [1]. Davis PD, et al. Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84. [2]. Slater MJ, et al. Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg Med Chem. 1999 Jun;7(6):1067-74. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 690.1±55.0 °C at 760 mmHg |
| Molecular Formula | C20H13N3O2 |
| Molecular Weight | 327.336 |
| Flash Point | 371.2±31.5 °C |
| Exact Mass | 327.100769 |
| PSA | 77.75000 |
| LogP | 3.21 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.811 |
| InChIKey | DQYBRTASHMYDJG-UHFFFAOYSA-N |
| SMILES | O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1c[nH]c2ccccc12 |
| Storage condition | -20℃ |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles29
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Synonyms
| MFCD00236432 |
| 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione |
| 2,3-bis-(1h-indol-3-yl)-maleimide |
| 3,4-Bis(3-indolyl)maleimide |
| 3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| 1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl- |
