Introduction：Basic information about CAS 51322-75-9|Tizanidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tizanidine |
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| CAS Number | 51322-75-9 | Molecular Weight | 253.71100 |
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| Density | 1.82 g/cm3 | Boiling Point | 391.2ºC at 760 mmHg |
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| Molecular Formula | C9H8ClN5S | Melting Point | 221 - 223ºC |
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| MSDS | / | Flash Point | 190.4ºC |
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Names
| Name | tizanidine |
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| Synonym | More Synonyms |
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Tizanidine BiologicalActivity
| Description | Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.Target: α2-adrenergic receptorTizanidine is a drug that is used as a muscle relaxant. It is a centrally acting α2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, ALS, spastic diplegia, back pain, or certain other injuries to the spine or central nervous system. It is also prescribed off-label for migraine headaches, as a sleep aid, and as an anticonvulsant. It is also prescribed for some symptoms of fibromyalgia.Tizanidine has been found to be as effective as other antispasmodic drugs and has superior tolerability to that of baclofen and diazepam. Tizanidine can be very strong even at the 2 mg dose and may cause hypotension, so caution is advised when it is used in patients who have a history of orthostatic hypotension, or when switching from gel cap to tablet form and vice versa. Tizanidine can occasionally cause liver damage, generally the hepatocellular type. Clinical trials show that up to 5% of patients treated with tizanidine had elevated liver function test values, though symptoms disappeared upon withdrawal of the drug. Care should be used when first beginning treatment with tizanidine with regular liver tests for the first 6 months of treatment. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Neurological Disease |
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| References | [1]. Kamen L, et al. A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. Curr Med Res Opin. 2008 Feb;24(2):425-39. |
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Chemical & Physical Properties
| Density | 1.82 g/cm3 |
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| Boiling Point | 391.2ºC at 760 mmHg |
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| Melting Point | 221 - 223ºC |
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| Molecular Formula | C9H8ClN5S |
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| Molecular Weight | 253.71100 |
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| Flash Point | 190.4ºC |
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| Exact Mass | 253.01900 |
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| PSA | 90.44000 |
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| LogP | 1.55320 |
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| InChIKey | XFYDIVBRZNQMJC-UHFFFAOYSA-N |
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| SMILES | Clc1ccc2nsnc2c1NC1=NCCN1 |
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| Storage condition | -20℃ |
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| Water Solubility | H2O: ~29 mg/mL |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DL0080000
- CHEMICAL NAME :
- 2,1,3-Benzothiadiazole, 5-chloro-4-(2-imidazolin-2-ylamino)-
- CAS REGISTRY NUMBER :
- 51322-75-9
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C9-H8-Cl-N5-S
- MOLECULAR WEIGHT :
- 253.73
- WISWESSER LINE NOTATION :
- T56 BNSNJ FM- BT5M CN BUTJ& GG
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Skin and Appendages - hair
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,793,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 235 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Skin and Appendages - hair
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,793,1980
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Safety Information
| Hazard Codes | Xn: Harmful; |
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| Risk Phrases | R22 |
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| Safety Phrases | 26-36 |
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| WGK Germany | 3 |
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| RTECS | DK9910000 |
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| HS Code | 2934999090 |
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Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine |
| 5-chloro-N-(imidazolidin-2-ylidene)-2,1,3-benzothiadiazol-4-amine |
| Sirdalud |
| Ternelin |
| [14C]-Tizanidine |
| Tizanidina [INN-Spanish] |
| Zanaflex(R) |
| Tizanidina |
| MFCD00798231 |
| Tizanidinum |
| Zanaflex |
| UNII-6AI06C00GW |
| 5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole |
| Tizanidinum [INN-Latin] |
