Introduction：Basic information about CAS 55321-99-8|3-hydroxypyrazine-2-carboxamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3-hydroxypyrazine-2-carboxamide |
|---|
| CAS Number | 55321-99-8 | Molecular Weight | 139.112 |
|---|
| Density | 1.5±0.1 g/cm3 | Boiling Point | 640.8±55.0 °C at 760 mmHg |
|---|
| Molecular Formula | C5H5N3O2 | Melting Point | ca 270℃ |
|---|
| MSDS | / | Flash Point | 341.3±31.5 °C |
|---|
Names
| Name | 3-Hydroxypyrazine-2-carboxamide |
|---|
| Synonym | More Synonyms |
|---|
3-hydroxypyrazine-2-carboxamide BiologicalActivity
| Description | T-1105, a novel broad-spectrum viral polymerase inhibitor, structural analogue of T-705, inhibits the polymerases of RNA viruses after being converted to ribonucleoside triphosphate (RTP) metabolite[1]. T-1105 has antiviral activity against various RNA viruses, including Zika virus (ZIKV), influenza virus, arenaviruses, bunyaviruses, West Nile virus (WNV), yellow fever virus (YFV), and foot-and-mouth disease virus (FMDV). T-1105 can be formed by nicotinamide mononucleotide adenylyltransferase[2]. |
|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>Infection |
|---|
| Target | Viral polymerase[1] |
|---|
| References | [1]. Huchting J, et al. Cell line-dependent activation and antiviral activity of T-1105, the non-fluorinated analogue of T-705 (favipiravir). Antiviral Res. 2019 Jul;167:1-5. [2]. Furuta Y, et al. T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections. Antiviral Res. 2009 Jun;82(3):95-102. |
|---|
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|
| Boiling Point | 640.8±55.0 °C at 760 mmHg |
|---|
| Melting Point | ca 270℃ |
|---|
| Molecular Formula | C5H5N3O2 |
|---|
| Molecular Weight | 139.112 |
|---|
| Flash Point | 341.3±31.5 °C |
|---|
| Exact Mass | 139.038177 |
|---|
| PSA | 89.10000 |
|---|
| LogP | 0.32 |
|---|
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
|---|
| Index of Refraction | 1.634 |
|---|
| InChIKey | SZPBAPFUXAADQV-UHFFFAOYSA-N |
|---|
| SMILES | NC(=O)c1ncc[nH]c1=O |
|---|
Safety Information
| Hazard Codes | Xi |
|---|
| Risk Phrases | 36/37/38 |
|---|
| Safety Phrases | 26-37 |
|---|
| HS Code | 2934999090 |
|---|
Customs
| HS Code | 2934999090 |
|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|---|
Synonyms
| Pyrazine-2-carboxamide, 3-hydroxy- |
| 2-pyrazinecarboxamide, 3-hydroxy- |
| 3-Oxo-3,4-dihydropyrazine-2-carboxamide |
| T6N DNJ BVZ CQ |
| T6MV DNJ CVZ |
| 2-oxo-1H-pyrazine-3-carboxamide |
| 3-hydroxypyrazine-2-carboxamide |
| Pyrazinecarboxamide, 3,4-dihydro-3-oxo- |
