CAS 55750-53-3|6-Maleimidocapronic acid
| Common Name | 6-Maleimidocapronic acid | ||
|---|---|---|---|
| CAS Number | 55750-53-3 | Molecular Weight | 211.214 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 407.3±28.0 °C at 760 mmHg |
| Molecular Formula | C10H13NO4 | Melting Point | 86-91ºC |
| MSDS | ChineseUSA | Flash Point | 200.1±24.0 °C |
| Symbol | GHS05, GHS07 | Signal Word | Danger |
Names
| Name | 6-Maleimidocaproic Acid |
|---|---|
| Synonym | More Synonyms |
6-Maleimidocapronic acid BiologicalActivity
| Description | 6-Maleimidocapronic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
| Target | Alkyl-Chain |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 407.3±28.0 °C at 760 mmHg |
| Melting Point | 86-91ºC |
| Molecular Formula | C10H13NO4 |
| Molecular Weight | 211.214 |
| Flash Point | 200.1±24.0 °C |
| Exact Mass | 211.084457 |
| PSA | 74.68000 |
| LogP | 0.71 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.537 |
| InChIKey | WOJKKJKETHYEAC-UHFFFAOYSA-N |
| SMILES | O=C(O)CCCCCN1C(=O)C=CC1=O |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H315-H318-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2925190090 |
Customs
| HS Code | 2925190090 |
|---|---|
| Summary | 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoic acid |
| MFCD00043140 |
| 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo- |
| 6-(2,5-dioxopyrrol-1-yl)hexanoic acid |
