CAS 5746-90-7|3-METHYLGLUTACONIC ACID

Introduction：Basic information about CAS 5746-90-7|3-METHYLGLUTACONIC ACID, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 3-METHYLGLUTACONIC ACID BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	3-METHYLGLUTACONIC ACID
CAS Number	5746-90-7	Molecular Weight	144.13
Density	1.307g/cm3	Boiling Point	399.4ºC at 760mmHg
Molecular Formula	C₆H₈O₄	Melting Point	101 - 105°C (lit.)
MSDS	/	Flash Point	209.5ºC

Names

Name	3-methylglutaconic acid
Synonym	More Synonyms

3-METHYLGLUTACONIC ACID BiologicalActivity

Description	3-Methylglutaconic acid is the major metabolites accumulating in 3-Methylglutaconic aciduria (MGTA). 3-Methylglutaconic acid can induce lipid oxidative damage and protein oxidative. 3-Methylglutaconic acid decreases the non-enzymatic antioxidant defenses in cerebral cortex supernatants to elicit oxidative stress in the cerebral cortex. 3-Methylglutaconic acid can be used for brain damage disease research[1].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>OthersSignaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Metabolic DiseaseResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor
References	[1]. Guilhian Leipnitz, et al. Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats. Life Sci. 2008 Mar 12;82(11-12):652-62. [2]. N L Alsip, et al. Cardiovascular effects of 3-mercaptopropionic acid and levels of GABA in regions of the brain of guinea-pigs. Neuropharmacology. 1984 Mar;23(3):349-57. [3]. E Girardi, et al. 3-mercaptopropionic acid-induced seizures decrease NR2B expression in Purkinje cells: cyclopentyladenosine effect. Cell Mol Neurobiol. 2010 Oct;30(7):985-90. [4]. Leipnitz G, et al. Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats. Life Sci. 2008 Mar 12;82(11-12):652-62.

Description

3-Methylglutaconic acid is the major metabolites accumulating in 3-Methylglutaconic aciduria (MGTA). 3-Methylglutaconic acid can induce lipid oxidative damage and protein oxidative. 3-Methylglutaconic acid decreases the non-enzymatic antioxidant defenses in cerebral cortex supernatants to elicit oxidative stress in the cerebral cortex. 3-Methylglutaconic acid can be used for brain damage disease research[1].

Related Catalog

Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>OthersSignaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Metabolic DiseaseResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor

References

[1]. Guilhian Leipnitz, et al. Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats. Life Sci. 2008 Mar 12;82(11-12):652-62.

[2]. N L Alsip, et al. Cardiovascular effects of 3-mercaptopropionic acid and levels of GABA in regions of the brain of guinea-pigs. Neuropharmacology. 1984 Mar;23(3):349-57.

[3]. E Girardi, et al. 3-mercaptopropionic acid-induced seizures decrease NR2B expression in Purkinje cells: cyclopentyladenosine effect. Cell Mol Neurobiol. 2010 Oct;30(7):985-90.

[4]. Leipnitz G, et al. Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats. Life Sci. 2008 Mar 12;82(11-12):652-62.

Chemical & Physical Properties

Density	1.307g/cm3
Boiling Point	399.4ºC at 760mmHg
Melting Point	101 - 105°C (lit.)
Molecular Formula	C₆H₈O₄
Molecular Weight	144.13
Flash Point	209.5ºC
Exact Mass	144.04200
PSA	74.60000
LogP	0.49200
Index of Refraction	1.508
InChIKey	WKRBKYFIJPGYQC-UHFFFAOYSA-N
SMILES	CC(=CC(=O)O)CC(=O)O
Storage condition	2-8°C

Synonyms

3-methyl-pentenedioic acid

3-METHYL-2-PENTENEDIOIC ACID

glutacouic acide 3-methyl

3-methylglutaric acid

3-Methylglutaconsaeure

3-METHYL-PENT-2-ENEDIOIC ACID

3-Methyl-pentendisaeure

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