Introduction：Basic information about CAS 211990-57-7|Ac-IETD-AFC (N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-Trifluoromethylcoumarin), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ac-IETD-AFC (N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-Trifluoromethylcoumarin) |
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| CAS Number | 211990-57-7 | Molecular Weight | 729.65500 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C31H38F3N5O12 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-[(2-acetamido-3-methylpentanoyl)amino]-5-[[1-[[3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| References | [1]. [1]Kazimierz Weglarczyk, et al. Caspase-8 activation precedes alterations of mitochondrial membrane potential during monocyte apoptosis induced by phagocytosis and killing of Staphylococcus aureus. Infect Immun. 2004 May;72(5):2590-7. [2]. Przemysław Reszka, et al. Synthesis, enzymatic evaluation, and docking studies of fluorogenic caspase 8 tetrapeptide substrates. ChemMedChem. 2010 Jan;5(1):103-17. |
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Chemical & Physical Properties
| Molecular Formula | C31H38F3N5O12 |
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| Molecular Weight | 729.65500 |
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| Exact Mass | 729.24700 |
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| PSA | 270.54000 |
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| LogP | 2.11240 |
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| InChIKey | CGUOWXRXLQXOKO-BYLHTXFJSA-N |
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| SMILES | CCC(C)C(NC(C)=O)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(CC(=O)O)C(=O)Nc1ccc2c(C(F)(F)F)cc(=O)oc2c1)C(C)O |
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Synonyms
| AFC140 |
| Ac-IGTD-AFC |
| Ac-Ile-Glu-Thr-Asp-AFC |
| Ac-Ile-Glu-Thr-Asp-7-Amino-4-trifluoromethylcoumarin |
