CAS 145307-34-2|A 77636 hydrochloride

Introduction：Basic information about CAS 145307-34-2|A 77636 hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. A 77636 hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	A 77636 hydrochloride
CAS Number	145307-34-2	Molecular Weight	365.89400
Density	/	Boiling Point	515.3ºC at 760 mmHg
Molecular Formula	C₂₀H₂₈ClNO₃	Melting Point	/
MSDS	ChineseUSA	Flash Point	265.5ºC

Names

Name	(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride
Synonym	More Synonyms

A 77636 hydrochloride BiologicalActivity

Description	A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor[1][2].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease
In Vivo	A-77636 (0.1-1 mg/kg) exerts a suppressant effect on food intake, due principally to a reduction in meal size and duration[3]. Animal Model: Male hooded rat[1] Dosage: 0.1, 0.3 and 1.0 mg/kg Administration: S.c. Result: Exerted a suppressant effect on food intake, due principally to a reduction in meal size and duration.
References	[1]. Kebabian JW, et al. A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur J Pharmacol. 1992;229(2-3):203-209. [2]. Smith LA, et al. The actions of a D-1 agonist in MPTP treated primates show dependence on both D-1 and D-2 receptor function and tolerance on repeated administration. J Neural Transm (Vienna). 2002;109(2):123-140. [3]. Cooper SJ, et al. The anorectic effect of the selective dopamine D1-receptor agonist A-77636 determined by meal pattern analysis in free-feeding rats. Eur J Pharmacol. 2006;532(3):253-257.

Chemical & Physical Properties

Boiling Point	515.3ºC at 760 mmHg
Molecular Formula	C₂₀H₂₈ClNO₃
Molecular Weight	365.89400
Flash Point	265.5ºC
Exact Mass	365.17600
PSA	75.71000
LogP	4.75760
Vapour Pressure	3.06E-11mmHg at 25°C
InChIKey	BWHPNJVKFAPVOG-QYFJGNGUSA-N
SMILES	Cl.NCC1OC(C23CC4CC(CC(C4)C2)C3)Cc2c1ccc(O)c2O
Storage condition	-20°C

Synonyms

A-77636 hydrochloride hydrate

(1R,3S)-3-(1'-adamantyl)-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride

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