Introduction：Basic information about CAS 55749-97-8|Litorin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Litorin |
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| CAS Number | 55749-97-8 | Molecular Weight | 1085.24 |
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| Density | 1.34 g/cm3 | Boiling Point | 1693.3ºC at 760 mmHg |
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| Molecular Formula | C51H68N14O11S | Melting Point | / |
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| MSDS | Chinese | Flash Point | 977.9ºC |
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Names
| Name | Litorin |
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| Synonym | More Synonyms |
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Litorin BiologicalActivity
| Description | Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in vivo[1][2]. |
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| Related Catalog | Research Areas >>Metabolic DiseaseSignaling Pathways >>GPCR/G Protein >>Bombesin Receptor |
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| In Vitro | 99mTc-Litorin is developed for non-invasive imaging of tumors with overexpressed gastrin-releasing peptide receptors (GRP-R)[1]. [D-Phe1,Leu8,9]Litorin inhibits binding of 125I-[Tyr4] BN to murine Swiss 3T3 cells with a Ki of 5.1 nM[2]. Litorin stimulates 3H-Thymidine incorporation in murine Swiss 3T3 cells with an EC50 of 2.3 nM[2]. |
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| In Vivo | Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in in vivo experiments[2]. |
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| References | [1]. Kam Leung. 99mTc-pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2. Molecular Imaging and Contrast Agent Database (MICAD). 2007 Oct 1. [2]. J M Siegfried, et al. Effects of bombesin and gastrin-releasing peptide on human bronchial epithelial cells from a series of donors: individual variation and modulation by bombesin analogs. Anat Rec. 1993 May;236(1):241-7. |
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Chemical & Physical Properties
| Density | 1.34 g/cm3 |
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| Boiling Point | 1693.3ºC at 760 mmHg |
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| Molecular Formula | C51H68N14O11S |
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| Molecular Weight | 1085.24 |
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| Flash Point | 977.9ºC |
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| Exact Mass | 1084.49000 |
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| PSA | 417.85000 |
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| LogP | 2.74370 |
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| Index of Refraction | 1.615 |
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| InChIKey | OHCNRADJYUSTIV-FPNHNIPFSA-N |
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| SMILES | CSCCC(NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1cnc[nH]1)NC(=O)CNC(=O)C(NC(=O)C(C)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCC(N)=O)NC(=O)C1CCC(=O)N1)C(C)C)C(N)=O |
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Synonyms
| 5-Oxo-L-Pro-L-Gln-L-Trp-L-Ala-L-Val-Gly-L-His-L-Phe-L-Met-NH2 |
| Efonidipine hydrochloride monoethanolate |
| M.W. 1084.47 C51H68N14O11S |
| pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2 |
| 2-De-L-Val-3-de-L-Pro-ranatensin |
| Pituitary adenylate cyclase activating fragment 21-38 |
| pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2,Pituitary adenylate cyclase activating fragment 21-38 |
| GLP-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2 |
| PYR-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2 |
