CAS 200959-48-4|Ac-RYYRIK-NH2 TFA
Introduction：Basic information about CAS 200959-48-4|Ac-RYYRIK-NH2 TFA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ac-RYYRIK-NH2 TFA | ||
|---|---|---|---|
| CAS Number | 200959-48-4 | Molecular Weight | 939.115 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C44H70N14O9 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Ac-RYYRIK-NH2 |
|---|---|
| Synonym | More Synonyms |
Ac-RYYRIK-NH2 TFA BiologicalActivity
| Description | Ac-RYYRIK-NH2 is a potent and partial agonist on ORL1 transfected in CHO cells (Kd=1.5 nM) and behaves as a endogenous ligand of ORL1. Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [35S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>Neurological Disease |
| Target | Kd: 1.5 nM (ORL1 transfected in CHO cells)[1] |
| In Vivo | Ac-RYYRIK-NH2 (intracerebroventricularly (i.c.v.) inhibits spontaneous locomotor activity in mice with an ID50 of 0.07 nmol. Co-administration of noc/OFQ and Ac-RYYRIK-NH2 lead to additive effects in Male Swiss mice[1]. |
| References | [1]. H Berger, et al. Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. Br J Pharmacol. 1999 Feb;126(3):555-8. [2]. H Berger, et al. The nociceptin/orphanin FQ receptor ligand acetyl-RYYRIK-amide exhibits antagonistic and agonistic properties.Peptides. 2000 Jul;21(7):1131-9. [3]. C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J Pharmacol Exp Ther. 1997 Nov;283(2):735-41. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C44H70N14O9 |
| Molecular Weight | 939.115 |
| Exact Mass | 938.545044 |
| PSA | 407.97000 |
| LogP | -1.04 |
| Index of Refraction | 1.644 |
| InChIKey | WBBBVZGQADABSU-RERZDIOCSA-N |
| SMILES | CCC(C)C(NC(=O)C(CCCN=C(N)N)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCCN=C(N)N)NC(C)=O)C(=O)NC(CCCCN)C(N)=O |
| Storage condition | -20°C |
Synonyms
| L-Lysinamide, N-acetyl-N-(diaminomethylene)-L-ornithyl-L-tyrosyl-L-tyrosyl-N-(diaminomethylene)-L-ornithyl-L-isoleucyl- |
| N-acetyl-N-(diaminomethylidene)-L-ornithyl-L-tyrosyl-L-tyrosyl-N-(diaminomethylidene)-L-ornithyl-L-isoleucyl-L-lysinamide |
| Ac-RYYRIK amide |
| AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2 |
| N-Acetyl-N-(diaminomethylene)-L-ornithyl-L-tyrosyl-L-tyrosyl-N-(diaminomethylene)-L-ornithyl-L-isoleucyl-L-lysinamide |
| ACETYL-RYYRIK,AMIDE |
