CAS 75704-24-4|(Rac)-WAY-161503
Introduction：Basic information about CAS 75704-24-4|(Rac)-WAY-161503, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (Rac)-WAY-161503 | ||
|---|---|---|---|
| CAS Number | 75704-24-4 | Molecular Weight | 308.59100 |
| Density | / | Boiling Point | 529ºC at 760 mmHg |
| Molecular Formula | C11H11Cl2N3O | Melting Point | / |
| MSDS | / | Flash Point | 273.7ºC |
Names
| Name | 8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one |
|---|
(Rac)-WAY-161503 BiologicalActivity
| Description | (Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects[1][2]. |
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| Related Catalog | Research Areas >>Metabolic DiseaseResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
| Target | 5-HT2C Receptor:4 nM (Ki) 5-HT2C Receptor:12 nM (EC50) |
| In Vivo | (Rac)-WAY-161503 (3-30 mg/kg; intraperitoneal injection; male C57BL/6J mice) treatment dose-dependently decreases locomotor activity, an effect that is blocked by the 5-HT2C/2B antagonist SER-082. Additionally, the decreased locomotor activity produced by 10 mg/kg DOI is potentiated in the 5-HT2A KO mice[1]. Animal Model: Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)[1] Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg Administration: Intraperitoneal injection Result: Dose-dependently decreased locomotor activity, an effect that was blocked by the 5-HT2C/2B antagonist SER-082. |
| References | [1]. Halberstadt AL, et al. 5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice. Neuropsychopharmacology. 2009 Jul;34(8):1958-67. [2]. Welmaker GS, et al. Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1991-4. |
Chemical & Physical Properties
| Boiling Point | 529ºC at 760 mmHg |
|---|---|
| Molecular Formula | C11H11Cl2N3O |
| Molecular Weight | 308.59100 |
| Flash Point | 273.7ºC |
| Exact Mass | 307.00500 |
| PSA | 44.37000 |
| LogP | 3.05750 |
| InChIKey | PHGWDAICBXUJDU-UHFFFAOYSA-N |
| SMILES | O=C1Nc2cc(Cl)c(Cl)cc2N2CCNCC12 |
