Introduction：Basic information about CAS 40254-90-8|NSC693868, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | NSC693868 |
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| CAS Number | 40254-90-8 | Molecular Weight | 185.18500 |
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| Density | 1.57g/cm3 | Boiling Point | 522.8ºC at 760mmHg |
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| Molecular Formula | C9H7N5 | Melting Point | / |
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| MSDS | / | Flash Point | 303ºC |
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Names
| Name | Cdk 1/5 Inhibitor |
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| Synonym | More Synonyms |
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NSC693868 BiologicalActivity
| Description | NSC693868 is a selective inhibitor of CDK1 and CDK5 with IC50s of 600 nM and 400 nM, respectively. NSC693868 less potently inhibits GSK3β with an IC50 of 1 µM) and does not block CDC25 activity. NSC693868 is used to help define the roles of CDK1 and CDK5 in various signaling pathways[1]. |
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| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>GSK-3Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>CDKSignaling Pathways >>PI3K/Akt/mTOR >>GSK-3 |
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| Target | Cdk1/cyclin B:600 nM (IC50) Cdk5/p25:400 nM (IC50) GSK-3β:1 μM (IC50) |
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| References | [1]. Ortega MA, et al. Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorg Med Chem. 2002 Jul;10(7):2177-84. |
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Chemical & Physical Properties
| Density | 1.57g/cm3 |
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| Boiling Point | 522.8ºC at 760mmHg |
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| Molecular Formula | C9H7N5 |
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| Molecular Weight | 185.18500 |
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| Flash Point | 303ºC |
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| Exact Mass | 185.07000 |
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| PSA | 80.48000 |
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| LogP | 1.66950 |
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| Index of Refraction | 1.9 |
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Safety Information
| Hazard Codes | T+ |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
