CAS 75644-90-5|(D-Ser2)-Leu-Enkephalin-Thr

Introduction：Basic information about CAS 75644-90-5|(D-Ser2)-Leu-Enkephalin-Thr, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (D-Ser2)-Leu-Enkephalin-Thr BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	(D-Ser2)-Leu-Enkephalin-Thr
CAS Number	75644-90-5	Molecular Weight	686.753
Density	1.3±0.1 g/cm3	Boiling Point	1163.0±65.0 °C at 760 mmHg
Molecular Formula	C₃₃H₄₆N₆O₁₀	Melting Point	/
MSDS	/	Flash Point	657.2±34.3 °C

Names

Name	dslet
Synonym	More Synonyms

(D-Ser2)-Leu-Enkephalin-Thr BiologicalActivity

Description	DSLET ([D-Ser2, Leu5, Thr6]-enkephalin) is a highly specific agonist of the δ-receptor. DSLET is an enkephalin-related peptide selectively bound to the δ opioid receptor[1][2].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>Neurological Disease
Target	δ Opioid Receptor/DOR
In Vitro	DSLET (0.1-1000 μM) 以剂量依赖性方式抑制霍乱毒素 (CT; HY-P1446) 诱导的 cAMP 生成[1]。
References	[1]. J L Nano, et al. Characterization of delta-opioid receptors and effect of enkephalins on IRD 98 rat epithelial intestinal cell line. Pflugers Arch. 2000 Mar;439(5):547-54. [2]. C S Goodchild, et al. Antinociception by intrathecal midazolam involves endogenous neurotransmitters acting at spinal cord delta opioid receptors. Br J Anaesth. 1996 Dec;77(6):758-63.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	1163.0±65.0 °C at 760 mmHg
Molecular Formula	C₃₃H₄₆N₆O₁₀
Molecular Weight	686.753
Flash Point	657.2±34.3 °C
Exact Mass	686.327515
PSA	269.51000
LogP	1.09
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.592
InChIKey	PKSODCLCMBUCPW-LVNBQDLPSA-N
SMILES	CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C(CO)NC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(C(=O)O)C(C)O
Storage condition	-20°C

Synonyms

M.W. 686.90 C33H46N6O10

L-Threonine, L-tyrosyl-D-serylglycyl-L-phenylalanyl-L-leucyl-

D-Ser2,Leu5,Thr6-enkephalin

L-Tyrosyl-D-serylglycyl-L-phenylalanyl-L-leucyl-L-threonine

Dislet

Dstle

TYR-D-SER-GLY-PHE-LEU-THR

2-Ser-Thr-Leu-enkephalin

[D-Ser2] Leu-Enkephalin-Thr

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