Introduction：Basic information about CAS 53251-94-8|L-Pinaverium bromide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | L-Pinaverium bromide |
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| CAS Number | 53251-94-8 | Molecular Weight | 591.416 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C26H41Br2NO4 | Melting Point | 159-164ºC |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethyl-4-bicyclo[3.1.1]heptanyl)ethoxy]ethyl]morpholin-4-ium,bromide |
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| Synonym | More Synonyms |
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L-Pinaverium bromide BiologicalActivity
| Description | Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients[1]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Others |
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| Target | Calcium channel[1]. |
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| References | [1]. Dai Y, et al. Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats. World J Gastroenterol. 2003 Mar;9(3):557-61. |
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Chemical & Physical Properties
| Melting Point | 159-164ºC |
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| Molecular Formula | C26H41Br2NO4 |
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| Molecular Weight | 591.416 |
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| Exact Mass | 589.140198 |
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| PSA | 36.92000 |
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| LogP | 2.25510 |
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| InChIKey | IKGXLCMLVINENI-UHFFFAOYSA-M |
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| SMILES | COc1cc(Br)c(C[N+]2(CCOCCC3CCC4CC3C4(C)C)CCOCC2)cc1OC.[Br-] |
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| Storage condition | -20°C Freezer |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- QF2810000
- CHEMICAL NAME :
- Morpholinium, 4-(2-bromo-4,5-dimethoxy)benzyl-4-(2-(2-(6,6-dimethyl -2-norpinyl)ethoxy) ethyl)-, bromide
- CAS REGISTRY NUMBER :
- 53251-94-8
- LAST UPDATED :
- 199109
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C26-H41-Br-N-O4.Br
- MOLECULAR WEIGHT :
- 591.50
- WISWESSER LINE NOTATION :
- L46 ATJ A1 A1 E2O2- AT6K DOTJ A1R BE DO1 EO1 &E &24/47
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 504 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 40,133,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 37 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,182,1974
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Synonyms
| 4-(6-Bromoveratryl)-4-[2-[2-(6,6-dimethyl-2-norpinyl)ethoxy]ethyl]morpholinium Bromide |
| LAT 1717 |
| Dicetel |
| EINECS 258-450-0 |
| Pinaverium bromide |
| UNII-7SCF54H12J |
| Morpholinium, 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]-, bromide (1:1) |
| 4-(2-Bromo-4,5-dimethoxybenzyl)-4-{2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl}morpholin-4-ium bromide |
| 4-[(2-Bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]morpholinium Bromide |
