CAS 997-68-2|Saccharopine
| Common Name | Saccharopine | ||
|---|---|---|---|
| CAS Number | 997-68-2 | Molecular Weight | 276.28600 |
| Density | 1.333g/cm3 | Boiling Point | 537.2ºC at 760mmHg |
| Molecular Formula | C11H20N2O6 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 278.7ºC |
Names
| Name | L-saccharopine |
|---|---|
| Synonym | More Synonyms |
Saccharopine BiologicalActivity
| Description | Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>Metabolic Disease |
| In Vitro | Saccharopine accumulation leads to mitochondrial damage and functional loss which is induced by saccharopine dehydrogenase (SDH) mutations of α-aminoadipate semialdehyde synthase (AASS)-1 in C. elegans[1]. |
| In Vivo | Saccharopine accumulation induces mitochondrial damage and progressive postnatal growth retardation in Aass mutant mice[1]. |
| References | [1]. Zhou J, et, al. The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. J Cell Biol. 2019 Feb 4;218(2):580-597. [2]. Leandro J, et, al. Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin. J Cell Biol. 2019 Feb 4;218(2):391-392. [3]. Papes F, et, al. Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse. Biochem J. 1999 Dec 1;344 Pt 2(Pt 2):555-63. |
Chemical & Physical Properties
| Density | 1.333g/cm3 |
|---|---|
| Boiling Point | 537.2ºC at 760mmHg |
| Molecular Formula | C11H20N2O6 |
| Molecular Weight | 276.28600 |
| Flash Point | 278.7ºC |
| Exact Mass | 276.13200 |
| PSA | 149.95000 |
| LogP | 0.56740 |
| Index of Refraction | 1.537 |
| InChIKey | ZDGJAHTZVHVLOT-YUMQZZPRSA-N |
| SMILES | NC(CCCCNC(CCC(=O)O)C(=O)O)C(=O)O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2922499990 |
Customs
| HS Code | 2922499990 |
|---|---|
| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
Articles35
More Articles| Attenuation of autophagic-proteolysis in C2C12 cells by saccharopine. Mol. Cell Biochem. 410 , 93-100, (2015) Muscle wasting impairs physical function and leads people to a bedridden state. We previously demonstrated that lysine (Lys) suppresses autophagic-proteolysis through the Akt pathway. However, the eff... | |
| Molecular cloning and expression of human L-pipecolate oxidase. Biochem. Biophys. Res. Commun. 270(3) , 1101-5, (2000) In higher eukaryotes L-lysine can be degraded via two distinct routes including the saccharopine pathway and the L-pipecolate pathway. The saccharopine pathway is the primary route of degradation of l... | |
| Lysine catabolism in Haemonchus contortus and Teladorsagia circumcincta. Exp. Parasitol. 131(1) , 101-6, (2012) Catabolism of lysine through the pipecolate, saccharopine and cadaverine pathways has been investigated in L3 and adult Haemonchus contortus and Teladorsagia circumcincta. Both enzymes of the saccharo... |
Synonyms
| L-SACCHAROPINE |
| L-Saccharopine |
