Introduction：Basic information about CAS 119425-89-7|Loureirin A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Loureirin A |
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| CAS Number | 119425-89-7 | Molecular Weight | 286.322 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 479.1±40.0 °C at 760 mmHg |
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| Molecular Formula | C17H18O4 | Melting Point | / |
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| MSDS | / | Flash Point | 175.8±20.8 °C |
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Names
| Name | Loureirin A |
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| Synonym | More Synonyms |
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Loureirin A BiologicalActivity
| Description | Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity. |
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| Related Catalog | Natural Products >>FlavonoidsResearch Areas >>Cardiovascular Disease |
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| Target | Akt |
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| In Vitro | Loureirin A (50 μM, 100 μM) inhibits collagen-induced platelet ATP secretion and thrombin-stimulated P-selectin expression in a dose-dependent manner. Loureirin A also significantly impairs platelet spreading on immobilized fibrinogen. Loureirin A almost completely eliminates collagen-induced Akt phosphorylation at Ser473 at the dose of 100 μM, and has an additive inhibitory effect with the phosphoinositide 3-kinase (PI3K) inhibitor Ly294002 on collage-induced Akt phosphorylation in platelets at 50 μM[1]. |
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| References | [1]. Hao HZ, et al. Antiplatelet activity of loureirin A by attenuating Akt phosphorylation: In vitro studies. Eur J Pharmacol. 2015 Jan 5;746:63-9. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 479.1±40.0 °C at 760 mmHg |
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| Molecular Formula | C17H18O4 |
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| Molecular Weight | 286.322 |
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| Flash Point | 175.8±20.8 °C |
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| Exact Mass | 286.120514 |
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| PSA | 55.76000 |
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| LogP | 3.30 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.573 |
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| InChIKey | RSAIVLRELNGZEY-UHFFFAOYSA-N |
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| SMILES | COc1ccc(CCC(=O)c2ccc(O)cc2)c(OC)c1 |
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| Storage condition | 2-8C |
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Synonyms
| 3-(2,4-Dimethoxyphenyl)-1-(4-hydroxyphenyl)propan-1-one |
| 3-(2,4-Dimethoxyphenyl)-1-(4-hydroxyphenyl)-1-propanone |
| 1-Propanone, 3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)- |
