Introduction：Basic information about CAS 1509-34-8|L-allo-Isoleucine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
L-Alloisoleucine is a branched chain amino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).
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Target
Human Endogenous Metabolite
Chemical & Physical Properties
Density
1.0±0.1 g/cm3
Boiling Point
225.8±23.0 °C at 760 mmHg
Melting Point
-285ºC
Molecular Formula
C6H13NO2
Molecular Weight
131.173
Flash Point
90.3±22.6 °C
Exact Mass
131.094635
PSA
63.32000
LogP
0.73
Vapour Pressure
0.0±0.9 mmHg at 25°C
Index of Refraction
1.463
InChIKey
AGPKZVBTJJNPAG-UHNVWZDZSA-N
SMILES
CCC(C)C(N)C(=O)O
Storage condition
Store at RT.
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
BA2933000
CHEMICAL NAME :
Alloisoleucine, L-
CAS REGISTRY NUMBER :
1509-34-8
BEILSTEIN REFERENCE NO. :
1721791
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C6-H13-N-O2
MOLECULAR WEIGHT :
131.20
WISWESSER LINE NOTATION :
QVYZY2&1 -L,ALLO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6954 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 58,253,1955
Interrelation between the metabolism of L-isoleucine and L-allo-isoleucine in patients with maple syrup urine disease.
Pediatr. Res. 25 , 11-14, (1989)
The nonprotein amino acid L-allo-isoleucine is formed endogenously in maple syrup urine disease patients from (R)-3-methyl-2-oxo-pentanoic acid. During strict metabolic balance, the plasma L-allo-isol...
Functional differences in the catabolism of branched-chain L-amino acids in cultured normal and maple syrup urine disease fibroblasts.
Biochem. Med. Metab. Biol. 41 , 105-116, (1989)
Possible functional differences in the catabolism of the four branched-chain L-amino acids in maple syrup urine disease were assessed using cultured human skin fibroblast stains. Transamination and ox...
Substrate specificity of L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase from Cephalosporium acremonium: demonstration of the structure of several unnatural tripeptide products.
Biochem. J. 301 , 367-372, (1994)
Potential substrates for L-delta-(alpha-aminoadipoyl)-L-(cysteinyl)-D-valine (ACV) synthetase were initially identified using both the amino-acid-dependent ATP<-->pyrophosphate exchange reaction catal...
