CAS 4312-32-7|Tetrahydrocoptisine

Introduction：Basic information about CAS 4312-32-7|Tetrahydrocoptisine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Tetrahydrocoptisine BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Tetrahydrocoptisine
CAS Number	4312-32-7	Molecular Weight	323.34300
Density	1.47g/cm3	Boiling Point	466.6ºC at 760mmHg
Molecular Formula	C₁₉H₁₇NO₄	Melting Point	221-222ºC
MSDS	/	Flash Point	142.5ºC

Names

Name	(.+-.)-Tetrahydrocoptisine
Synonym	More Synonyms

Tetrahydrocoptisine BiologicalActivity

Description	Tetrahydrocoptisine is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities.IC50 value:Target:in vitro: THC significantly inhibited LPS-induced TNF-α, interleukin-6(IL-6) and nitric oxide (NO) production. THC inhibited the production of TNF-α and IL-6 by down-regulating LPS-induced IL-6 and TNF-α mRNA expression [1].in vivo: Pretreatment with THC (i.p.) inhibited the paw and ear edema in the carrageenan-induced paw edema assay and xylene-induced ear edema assay, respectively. In the lipopolysaccharide (LPS)-induced systemic inflammation model, THC significantly inhibited serum tumor necrosis factor-alpha (TNF-α) release in mice [1]. Pretreatment of THC at doses of 10 and 20mg/kg bodyweight significantly attenuated the gastric lesions as compared to the ethanol group [2].
Related Catalog	Signaling Pathways >>Others >>OthersNatural Products >>AlkaloidResearch Areas >>Inflammation/Immunology
References	[1]. Li W, et al. Anti-inflammatory effect of tetrahydrocoptisine from Corydalis impatiens is a function of possible inhibition of TNF-α, IL-6 and NO production in lipopolysaccharide-stimulated peritoneal macrophages through inhibiting NF-κB activation and MAP [2]. Li W, et al. Protective effect of tetrahydrocoptisine against ethanol-induced gastric ulcer in mice. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):21-9.

Description

Tetrahydrocoptisine is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities.IC50 value:Target:in vitro: THC significantly inhibited LPS-induced TNF-α, interleukin-6(IL-6) and nitric oxide (NO) production. THC inhibited the production of TNF-α and IL-6 by down-regulating LPS-induced IL-6 and TNF-α mRNA expression [1].in vivo: Pretreatment with THC (i.p.) inhibited the paw and ear edema in the carrageenan-induced paw edema assay and xylene-induced ear edema assay, respectively. In the lipopolysaccharide (LPS)-induced systemic inflammation model, THC significantly inhibited serum tumor necrosis factor-alpha (TNF-α) release in mice [1]. Pretreatment of THC at doses of 10 and 20mg/kg bodyweight significantly attenuated the gastric lesions as compared to the ethanol group [2].

Related Catalog

Signaling Pathways >>Others >>OthersNatural Products >>AlkaloidResearch Areas >>Inflammation/Immunology

References

[1]. Li W, et al. Anti-inflammatory effect of tetrahydrocoptisine from Corydalis impatiens is a function of possible inhibition of TNF-α, IL-6 and NO production in lipopolysaccharide-stimulated peritoneal macrophages through inhibiting NF-κB activation and MAP

[2]. Li W, et al. Protective effect of tetrahydrocoptisine against ethanol-induced gastric ulcer in mice. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):21-9.

Chemical & Physical Properties

Density	1.47g/cm3
Boiling Point	466.6ºC at 760mmHg
Melting Point	221-222ºC
Molecular Formula	C₁₉H₁₇NO₄
Molecular Weight	323.34300
Flash Point	142.5ºC
Exact Mass	323.11600
PSA	40.16000
LogP	2.73740
InChIKey	UXYJCYXWJGAKQY-UHFFFAOYSA-N
SMILES	c1cc2c(c3c1CC1c4cc5c(cc4CCN1C3)OCO5)OCO2
Storage condition	2-8℃

Safety Information

HS Code	2934999090

Customs

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

Chelidamine

Trahydocoptisine

DL-Stylopine

DL-Tetrahydrocoptisine

TETRAHYDROCOPTISINE

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