CAS 1158838-45-9|Aurora A Inhibitor I
Introduction：Basic information about CAS 1158838-45-9|Aurora A Inhibitor I, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Aurora A Inhibitor I | ||
|---|---|---|---|
| CAS Number | 1158838-45-9 | Molecular Weight | 588.075 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C31H31ClFN7O2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | N-(2-chlorophenyl)-4-[[2-[4-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]anilino]-5-fluoropyrimidin-4-yl]amino]benzamide |
|---|---|
| Synonym | More Synonyms |
Aurora A Inhibitor I BiologicalActivity
| Description | Aurora A inhibitor I is a potent and highly selective Aurora A inhibitor with with an IC50 of 3.4 nM. |
|---|---|
| Related Catalog | Research Areas >>Cancer |
| Target | Aurora A:3.4 nM (IC50) Aurora B:3.4 μM (IC50) |
| In Vitro | Aurora A inhibitor I is exceptionally selective Aurora A inhibitors. Aurora A inhibitor I is an useful tool compounds for investigating the cellular role of Aurora A kinases without the complication of also inhibiting Aurora B[1]. |
| References | [1]. Aliagas-Martin I, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Huang OW, Hunsaker T, Kleinheinz T, Krueger E, Liang J, Moffat J, Phillips G, Pulk R, Rawson TE, Ultsch M, Walker L, Wiesmann C, Zhang B, Zhu BY, Cochran AG.A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.J Med Chem. 2009 May 28;52(10):3300-7. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C31H31ClFN7O2 |
| Molecular Weight | 588.075 |
| Exact Mass | 587.221191 |
| PSA | 102.49000 |
| LogP | 4.39 |
| Appearance of Characters | white to beige |
| Index of Refraction | 1.679 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: soluble10mg/mL, clear |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xn |
| Risk Phrases | 22 |
| RIDADR | NONH for all modes of transport |
Synonyms
| Aurora-A Inhibitor I |
| N-(2-Chlorophenyl)-4-{[2-({4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl}amino)-5-fluoro-4-pyrimidinyl]amino}benzamide |
| Aurora A inhibitor 1 |
| 2,4-Bisanilinopyrimidine,10 |
| Aurora A Inhibitor I |
| N-(2-chlorophenyl)-4-{[2-({4-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]amino}benzamide |
| N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]benzamide |
| S1451_Selleck |
| HMS3265K21 |
