Introduction：Basic information about CAS 146474-00-2|Mal-NH2 TFA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mal-NH2 TFA |
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| CAS Number | 146474-00-2 | Molecular Weight | 254.163 |
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| Density | / | Boiling Point | 278.1ºC at 760 mmHg |
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| Molecular Formula | C8H9F3N2O4 | Melting Point | 124ºC |
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| MSDS | ChineseUSA | Flash Point | 122ºC |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | 1-(2-Aminoethyl)-1H-pyrrole-2,5-dione 2,2,2-trifluoroacetate |
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| Synonym | More Synonyms |
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Mal-NH2 TFA BiologicalActivity
| Description | Mal-NH2 (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Alkyl-Chain |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
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Chemical & Physical Properties
| Boiling Point | 278.1ºC at 760 mmHg |
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| Melting Point | 124ºC |
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| Molecular Formula | C8H9F3N2O4 |
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| Molecular Weight | 254.163 |
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| Flash Point | 122ºC |
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| Exact Mass | 254.051437 |
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| PSA | 100.70000 |
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| LogP | 0.14160 |
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| Vapour Pressure | 0.00436mmHg at 25°C |
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| InChIKey | YNHKVOGCDPODMT-UHFFFAOYSA-N |
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| SMILES | NCCN1C(=O)C=CC1=O.O=C(O)C(F)(F)F |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26 |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2925190090 |
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Customs
| HS Code | 2925190090 |
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| Summary | 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| Acetic acid, 2,2,2-trifluoro-, compd. with 1-(2-aminoethyl)-1H-pyrrole-2,5-dione (1:1) |
| MFCD01073617 |
| N-(2-Aminoethyl)maleimide trifluoroacetic acid salt |
| 1-(2-aminoethyl)pyrrole-2,5-dione,2,2,2-trifluoroacetic acid |
| 1-(2-Aminoethyl)-1H-pyrrole-2,5-dione trifluoroacetate (1:1) |
| 2-Maleimidoethylamine trifluoroacetate salt |
| N-(2-AMINOETHYL)MALEIMIDETRIFLUOROACETA |
